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<p>We studied the effect of α<sub>2</sub>-adrenergic receptors stimulation against the background of <i>I</i><sub>f</sub> blockade on the function Langendorff-isolated rat heart during the acute stage of myocardial infarction. Stimulation of α<sub>2</sub>-adrenergic receptors against the background of ZD7288 blocker (10<sup>–9</sup>, 10<sup>–5</sup> M) decreased HR, increased the left-ventricular developed pressure and the temporal and velocity characteristics of left-ventricular myocardial contraction, produced a multidirectional effects on coronary flow and duration of left-ventricular myocardial contraction in rats with acute myocardial infarction.</p>

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Effect of α2-Adrenergic Receptors Stimulation after If Blockade on the Heart of Rats with Acute Myocardial Infarction

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • A. M. Kuptsova,
  • N. I. Ziyatdinova,
  • L. I. Faskhutdinov,
  • R. R. Shakirov,
  • R. E. Dementieva,
  • T. L. Zefirov

摘要

We studied the effect of α2-adrenergic receptors stimulation against the background of If blockade on the function Langendorff-isolated rat heart during the acute stage of myocardial infarction. Stimulation of α2-adrenergic receptors against the background of ZD7288 blocker (10–9, 10–5 M) decreased HR, increased the left-ventricular developed pressure and the temporal and velocity characteristics of left-ventricular myocardial contraction, produced a multidirectional effects on coronary flow and duration of left-ventricular myocardial contraction in rats with acute myocardial infarction.