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<p>Recombinant modified vaccinia virus Ankara (rMVA) viruses expressing two forms of SARS-CoV-2 receptor-binding domain (RBD) of S protein fused to viral N protein were constructed and the immunogenicity of these rMVA was evaluated in BALB/c mice. Vaccination of animals with these vaccine vectors led to the production of SARS-CoV-2 neutralizing antibodies and induced a T-cell response targeting both RBD and N proteins.</p>

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An MVA-Based Vector Expressing the SARS-CoV-2 RBD Fused to N Protein Induces Neutralizing Antibodies and T-Cell Immune Response in Mice

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • D. V. Glazkova,
  • R. R. Mintaev,
  • O. V. Orlova,
  • B. V. Belugin,
  • G. A. Shipulin,
  • E. V. Bogoslovskaya

摘要

Recombinant modified vaccinia virus Ankara (rMVA) viruses expressing two forms of SARS-CoV-2 receptor-binding domain (RBD) of S protein fused to viral N protein were constructed and the immunogenicity of these rMVA was evaluated in BALB/c mice. Vaccination of animals with these vaccine vectors led to the production of SARS-CoV-2 neutralizing antibodies and induced a T-cell response targeting both RBD and N proteins.