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<p>The monocrotaline (MCT) rat model of pulmonary arterial hypertension (PAH) was employed to assess the effects of hindlimb denervation (HLD) on the weight of the lungs, heart, and heart subdivisions, as well as the parameters of circulation system and survival of the rats. MCT significantly increased the weight of the lungs, increased weight of the right ventricle of the heart as a trend, and significantly decreased the left ventricle weight. HLD significantly decreased the right ventricle weight, but did not change the left ventricle weight. HLD performed in MCT-treated rats normalized the lung weight, but did not change the weight of both ventricles in comparison with those in the group of MCT-treated rats. HLD significantly decreased the mean systemic BP in comparison with the control. MCT elevated the mean pressure in the right ventricle, whereas HLD performed in MCT-treated rats normalized this parameter. HLD increased the lifetime of rats with PAH by 25% despite of MCT-induced pulmonary hemorrhage, which is non-typical for PAH in humans. The results highlight the therapeutic vista for PAH and systemic arterial hypertension based on transient blockade of the somatic nerves according to Vishnevsky in contrast to precarious denervation of renal or pulmonary arteries. The alternative non-denervation methods to retard the development of PAH in patients expecting the donor material for transplantation of the lungs and heart are discussed.</p>

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Effect of Hindlimb Denervation on Survival Rate and Circulation and Respiration Systems in Monocrotaline Rat Model of Pulmonary Arterial Hypertension

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • S. V. Revenko,
  • I. A. Tarakanov,
  • L. N. Tikhomirova,
  • T. A. Kuropatkina,
  • I. Yu. Gavrilov,
  • M. N. Karpova,
  • L. V. Kuznetsova,
  • N. Yu. Klishina

摘要

The monocrotaline (MCT) rat model of pulmonary arterial hypertension (PAH) was employed to assess the effects of hindlimb denervation (HLD) on the weight of the lungs, heart, and heart subdivisions, as well as the parameters of circulation system and survival of the rats. MCT significantly increased the weight of the lungs, increased weight of the right ventricle of the heart as a trend, and significantly decreased the left ventricle weight. HLD significantly decreased the right ventricle weight, but did not change the left ventricle weight. HLD performed in MCT-treated rats normalized the lung weight, but did not change the weight of both ventricles in comparison with those in the group of MCT-treated rats. HLD significantly decreased the mean systemic BP in comparison with the control. MCT elevated the mean pressure in the right ventricle, whereas HLD performed in MCT-treated rats normalized this parameter. HLD increased the lifetime of rats with PAH by 25% despite of MCT-induced pulmonary hemorrhage, which is non-typical for PAH in humans. The results highlight the therapeutic vista for PAH and systemic arterial hypertension based on transient blockade of the somatic nerves according to Vishnevsky in contrast to precarious denervation of renal or pulmonary arteries. The alternative non-denervation methods to retard the development of PAH in patients expecting the donor material for transplantation of the lungs and heart are discussed.