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<p>The study of the newly synthesized 4,10-di(ethoxyacetyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,03,11,05,9]dodecane (from the class of hexaazaisovyurcitanes) has revealed that the compound when administered intragastrically and intraperitoneally exhibits high antinociceptive efficacy in tests of nociception of different genesis (chemogenic, thermal, mixed) comparable and/or superior to the effect of Tramadol.</p>

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Antinociceptive Action of New Water-Soluble Molecule, a Representative of Hexaazaisowurtzitane Class

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • S. G. Krylova,
  • E. A. Kiseleva,
  • D. A. Kulagina,
  • T. N. Povet’eva,
  • P. V. Kul’pin,
  • V. V. Eremina,
  • N. A. Alekseeva,
  • M. Yu. Minakova,
  • E. P. Zueva,
  • S. V. Sysolyatin,
  • V. V. Zhdanov

摘要

The study of the newly synthesized 4,10-di(ethoxyacetyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,03,11,05,9]dodecane (from the class of hexaazaisovyurcitanes) has revealed that the compound when administered intragastrically and intraperitoneally exhibits high antinociceptive efficacy in tests of nociception of different genesis (chemogenic, thermal, mixed) comparable and/or superior to the effect of Tramadol.