Scholarlink

<p>We studied the effects of glucose and glutamine deficiency on the survival of astrocytes after ischemic injury and examined the mechanisms of cell death. It was found that glutamine can serve as an alternative energy substrate that maintains oxidative phosphorylation and glycolysis in astrocytes. However, the combination of glucose and glutamine reduced the ischemia-induced increase in intracellular calcium and the expression of proapoptotic proteins to a greater extent. The results of the study indicate the possibility of using glutamine to maintain the viability of brain cells under conditions of oxygen and energy substrate deprivation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparison of Glucose and Glutamine as Energy Substrates for Astrocytes under Conditions of Oxygen Deficiency

  • 期刊论文

  • 发表日期：

    2025年9月1日

查看全文
  • E. A. Turovsky,
  • V. A. Babenko,
  • E. G. Varlamova,
  • E. Y. Plotnikov,
  • N. V. Andrianova

摘要

We studied the effects of glucose and glutamine deficiency on the survival of astrocytes after ischemic injury and examined the mechanisms of cell death. It was found that glutamine can serve as an alternative energy substrate that maintains oxidative phosphorylation and glycolysis in astrocytes. However, the combination of glucose and glutamine reduced the ischemia-induced increase in intracellular calcium and the expression of proapoptotic proteins to a greater extent. The results of the study indicate the possibility of using glutamine to maintain the viability of brain cells under conditions of oxygen and energy substrate deprivation.