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<p>We performed a comparative analysis of lipid and cholesterol metabolism disorders, as well as liver condition in male Wistar rats receiving high-fat diets with different cholesterol contents. Addition of 2% cholesterol to the diet resulted in a marked aggravation of fatty liver disease, characterized by extreme accumulation of fat and cholesterol. A diet supplemented with 0.5% cholesterol resulted in serum cholesterol accumulation and liver steatosis, but had no effect on weight gain or body composition. Introduction of 1% cholesterol to the diet induced similar abnormalities as 2% cholesterol, but without the extreme cholesterol and fat accumulation in the liver. This model can be used in the future to evaluate the effectiveness of the studied functional foods.</p>

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Alimentary Disorders of Cholesterol and Fat Metabolism in Male Wistar Rats: an In Vivo Study

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • N. A. Biryulina,
  • V. K. Mazo,
  • N. A. Petrov,
  • Yu. S. Sidorova,
  • A. A. Kochetkova

摘要

We performed a comparative analysis of lipid and cholesterol metabolism disorders, as well as liver condition in male Wistar rats receiving high-fat diets with different cholesterol contents. Addition of 2% cholesterol to the diet resulted in a marked aggravation of fatty liver disease, characterized by extreme accumulation of fat and cholesterol. A diet supplemented with 0.5% cholesterol resulted in serum cholesterol accumulation and liver steatosis, but had no effect on weight gain or body composition. Introduction of 1% cholesterol to the diet induced similar abnormalities as 2% cholesterol, but without the extreme cholesterol and fat accumulation in the liver. This model can be used in the future to evaluate the effectiveness of the studied functional foods.