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<p>In this study, an affinity matrix based on recombinant human angiotensin-converting enzyme 2 (ACE2) immobilized on a porous polymeric substrate was developed and characterized. The matrix efficiently binds viral particles pseudotyped with the SARS-CoV-2 spike protein. These findings highlight the prospects for creating novel affinity matrices for extracorporeal hemoperfusion aimed at reducing viral load in patients with high viremia and severe COVID-19.</p>

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Specific Matrix on the Basis of Angiotensin-Converting Enzyme 2: Development and Functional Analysis

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • N. N. Kostin,
  • T. V. Bobik,
  • N. Yu. Rushkevich,
  • G. A. Skryabin,
  • E. N. Kaliberda,
  • V. D. Knorre,
  • I. V. Smirnov,
  • A. G. Gabibov

摘要

In this study, an affinity matrix based on recombinant human angiotensin-converting enzyme 2 (ACE2) immobilized on a porous polymeric substrate was developed and characterized. The matrix efficiently binds viral particles pseudotyped with the SARS-CoV-2 spike protein. These findings highlight the prospects for creating novel affinity matrices for extracorporeal hemoperfusion aimed at reducing viral load in patients with high viremia and severe COVID-19.