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<p>We evaluated the efficiency of transplantation of a gene-cell construct based on olfactory ensheathing cells expressing neurotrophic NGF in female Wistar rats with an experimental model of Alzheimer’s disease. NGF improved long-term memory and learning ability in the passive avoidance test at week 3 after cell transplantation.</p>

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The Study of Cognitive Functions of Rats with Experimental Alzheimer’s Disease after Transplantation of Transduced Olfactory Ensheathing Cells Expressing Nerve Growth Factor

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • E. K. Karsuntseva,
  • A. D. Voronova,
  • V. S. Shishkina,
  • V. Yu. Pokidko,
  • A. I. Mukhina,
  • A. V. Chadin,
  • G. A. Fursa,
  • A. V. Fedorov,
  • O. V. Stepanova,
  • V. P. Chekhonin

摘要

We evaluated the efficiency of transplantation of a gene-cell construct based on olfactory ensheathing cells expressing neurotrophic NGF in female Wistar rats with an experimental model of Alzheimer’s disease. NGF improved long-term memory and learning ability in the passive avoidance test at week 3 after cell transplantation.