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<p>The endogenous intoxication level was assessed based on the content of medium-weight molecules (MWM) and LPO products in the blood serum of women with uncomplicated pregnancy depending on the gestational age: 6-12, 18-22, 28-32, and 38-40 weeks. A significant increase in the MWM level at λ = 280 nm was found at weeks 28-32 compared to the second trimester (<i>p</i> = 0.05), as well as before delivery compared to the first trimester (<i>p</i> = 0.013). In the third trimester of pregnancy and before delivery, the substrates with double bonds and diene conjugates content increased (<i>p</i> &lt; 0.05), but the levels of highly toxic TBA-active products before delivery did not differ from that at the beginning of the gestation process. These phase changes in LPO processes correspond to changes in the hormonal status of the body during uncomplicated pregnancy, and MWM measured at λ = 280 nm is a sensitive marker for monitoring of the endogenous intoxication level.</p>

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Indicators of Endogenous Intoxication in Uncomplicated Pregnancy. Medium-Weight Molecules and Lipid Peroxidation Products

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • N. V. Semenova,
  • O. A. Nikitina,
  • E. A. Novikova,
  • A. N. Karacheva,
  • A. Yu. Marianian,
  • S. I. Kolesnikov,
  • A. V. Labygina,
  • L. I. Kolesnikova

摘要

The endogenous intoxication level was assessed based on the content of medium-weight molecules (MWM) and LPO products in the blood serum of women with uncomplicated pregnancy depending on the gestational age: 6-12, 18-22, 28-32, and 38-40 weeks. A significant increase in the MWM level at λ = 280 nm was found at weeks 28-32 compared to the second trimester (p = 0.05), as well as before delivery compared to the first trimester (p = 0.013). In the third trimester of pregnancy and before delivery, the substrates with double bonds and diene conjugates content increased (p < 0.05), but the levels of highly toxic TBA-active products before delivery did not differ from that at the beginning of the gestation process. These phase changes in LPO processes correspond to changes in the hormonal status of the body during uncomplicated pregnancy, and MWM measured at λ = 280 nm is a sensitive marker for monitoring of the endogenous intoxication level.