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<p>The functional potential of mesenchymal stem cells (MSC) isolated from Bichat’s fat pad for osteoinduction in dentistry was compared with that of MSC from the adipose tissue and bone marrow. Functional activity of MSC was evaluated by the rate of their proliferation, migration, and differentiation into osteoblasts under the influence of erythropoietin. MSC from the Bichat’s fat pad have higher proliferative activity than MSC from the adipose tissue or bone marrow under the influence of platelet-enriched plasma. Moreover, they are characterized by low migration activity, differentiate into osteoblasts, and intensively produce alkaline phosphatase under the influence of erythropoietin. The revealed functional potential of MSC from the Bichat’s fat pad makes them promising for cell therapy, including osteoinduction in dentistry.</p>

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Comparative Evaluation of the Functional Potential of Mesenchymal Stem Cells from the Bichat’s Fat Pad, Bone Marrow, and Adipose Tissue for Bone Tissue Regeneration

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • N. A. Bondarenko,
  • M. A. Surovtseva,
  • I. I. Kim,
  • S. V. Ostapets,
  • O. S. Kosareva,
  • M. N. Drovosekov,
  • O. V. Poveshchenko

摘要

The functional potential of mesenchymal stem cells (MSC) isolated from Bichat’s fat pad for osteoinduction in dentistry was compared with that of MSC from the adipose tissue and bone marrow. Functional activity of MSC was evaluated by the rate of their proliferation, migration, and differentiation into osteoblasts under the influence of erythropoietin. MSC from the Bichat’s fat pad have higher proliferative activity than MSC from the adipose tissue or bone marrow under the influence of platelet-enriched plasma. Moreover, they are characterized by low migration activity, differentiate into osteoblasts, and intensively produce alkaline phosphatase under the influence of erythropoietin. The revealed functional potential of MSC from the Bichat’s fat pad makes them promising for cell therapy, including osteoinduction in dentistry.