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<p>We studied the ability of human macrophage conditioned media to inhibit differentiation of lung fibroblasts <i>in vitro</i>. The results showed that the conditioned medium of M-CSF-differentiated non-polarized macrophages (induced by macrophage CSF) suppressed TGF-β-induced differentiation, reduced the expression of myofibroblast markers (α-smooth muscle actin and vimentin), and decreased the contractile activity of lung myofibroblasts, while the conditioned media of dexamethasone-polarized macrophages and GM-CSF-differentiated non-polarized macrophages (differentiation stimulus is granulocyte-macrophage CSF) produced no such effects. Thus, the obtained data indicate the antifibrogenic potential of non-polarized M-CSF-differentiated macrophages.</p>

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Effect of Human Macrophage Conditioned Media on TGF-β-Induced Differentiation of Lung Fibroblasts

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • A. A. Maksimova,
  • E. Ya. Shevela,
  • M. A. Tikhonova,
  • I. M. Rashchupkin,
  • A. A. Ostanin,
  • E. R. Chernykh

摘要

We studied the ability of human macrophage conditioned media to inhibit differentiation of lung fibroblasts in vitro. The results showed that the conditioned medium of M-CSF-differentiated non-polarized macrophages (induced by macrophage CSF) suppressed TGF-β-induced differentiation, reduced the expression of myofibroblast markers (α-smooth muscle actin and vimentin), and decreased the contractile activity of lung myofibroblasts, while the conditioned media of dexamethasone-polarized macrophages and GM-CSF-differentiated non-polarized macrophages (differentiation stimulus is granulocyte-macrophage CSF) produced no such effects. Thus, the obtained data indicate the antifibrogenic potential of non-polarized M-CSF-differentiated macrophages.