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<p>The study examined the quantitative variations in the levels of pro-oncogenic miRNAs (miRNA-21, miRNA-27a, and miRNA-221) and tumor-suppressive miRNA-429 in blood serum and lymph of female Wistar rats with breast cancer after photodynamic therapy and controls (without treatment). The levels of pro-oncogenic miRNA-21 and miRNA-221 in the blood serum and lymph increased in the control group. Photodynamic therapy significantly reduced the levels of these miRNAs, suggesting the effectiveness of the treatment. The levels of pro-oncogenic miRNA-27a in the blood serum and lymph of both groups were multidirectional. The levels of tumor-suppressing miRNA-429 decreased significantly in the control group and remained low after photodynamic therapy. Therefore, miRNA-21 and miRNA-221 in the blood serum and lymph can be used as markers of the effectiveness of photodynamic therapy.</p>

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Quantitative Changes in MicroRNAs in Blood Serum and Lymph after Photodynamic Therapy in Experimental Breast Cancer

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • A. V. Kabakov,
  • O. V. Kazakov,
  • A. F. Poveshchenko,
  • V. N. Cherkas,
  • V. V. Kononchuk,
  • T. S. Kalinina,
  • N. R. Bodrova

摘要

The study examined the quantitative variations in the levels of pro-oncogenic miRNAs (miRNA-21, miRNA-27a, and miRNA-221) and tumor-suppressive miRNA-429 in blood serum and lymph of female Wistar rats with breast cancer after photodynamic therapy and controls (without treatment). The levels of pro-oncogenic miRNA-21 and miRNA-221 in the blood serum and lymph increased in the control group. Photodynamic therapy significantly reduced the levels of these miRNAs, suggesting the effectiveness of the treatment. The levels of pro-oncogenic miRNA-27a in the blood serum and lymph of both groups were multidirectional. The levels of tumor-suppressing miRNA-429 decreased significantly in the control group and remained low after photodynamic therapy. Therefore, miRNA-21 and miRNA-221 in the blood serum and lymph can be used as markers of the effectiveness of photodynamic therapy.