Background <p>In nuclear medicine, radiopharmaceutical drugs (RPDs) containing the technetium isotope Tc-99m are used to treat oncological diseases, such as brain, thyroid, and salivary gland cancer, as well as for diagnostic studies of the cardiovascular system. These RPDs are created using a&#xa0;molybdenum-technetium Tc-99m generator.</p> Aim <p>To determine the main parameters of complex protection for a&#xa0;designed transport container of a&#xa0;technetium generator for the production of RPDs in accordance with the GMP standard.</p> Materials and methods <p>Eighteen container material options were considered. To assess the protective characteristics of the container, we used the MicroShield v.&#xa0;8.01 software. Transport indices and categories of all container options were determined taking into account the calculated rate of equivalent doses for gamma radiation from the Mo-99/Tc-99m sorption column and the nominal source activity.</p> Results <p>We have simulated an advanced protective container for the Tc-99m generator. The best protective characteristics are noted for the option combining tungsten and lead&#xa0;2.5 and 3.5 cm thick, respectively.</p> Conclusion <p>This complex design of the protective container ensures the safe operation and transportation of the Tc-99m generator.</p>