Scholarlink

<p>Bile acids (BAs) play a crucial role in fish physiology, influencing digestion, lipid metabolism, osmoregulation, and endocrine function. Synthesized in the liver from cholesterol, they facilitate lipid emulsification and absorption in the intestine. Unlike mammals, fish exhibit species-specific variations in bile acid composition, reflecting their diverse evolutionary adaptations and dietary habits. The gut microbiota and environmental factors influence the production of primary and secondary bile acids in fish, thereby affecting their metabolic and physiological functions. Beyond digestion, bile acids act as signalling molecules by modulating nuclear and membrane receptors, such as the Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5), modulating energy metabolism, immune responses, and stress adaptation in aquatic environments. Recent studies suggest that bile acids influence fish growth, reproduction, and disease resistance, making them valuable in aquaculture for improving feed efficiency and health management. Additionally, dietary BA supplementation has shown potential in mitigating lipid peroxidation and enhancing intestinal integrity, particularly under intensive farming conditions. However, excessive accumulation can lead to hepatotoxicity, underscoring the need for a balanced approach to their application in fish nutrition. Advances in analytical methods, particularly liquid chromatography-mass spectrometry (LC–MS), have facilitated a detailed profiling of BAs across fish species, offering insights into their physiological significance and potential biotechnological applications. This review comprehensively analyzes the metabolism, function, and emerging role of BAs in aquaculture, highlighting current research gaps and future directions for optimizing fish health and production. Understanding the dynamics of bile acids in fish can contribute to sustainable aquaculture practices by enhancing nutrient utilization, stress resilience, and disease management strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Optimizing aquafeeds with bile acids in fish physiology and aquaculture: implications for growth, health, and sustainable aquaculture practices

  • 期刊论文

  • 发表日期：

    2025年12月15日

查看全文
  • Panneerselvam Dheeran,
  • Vishwajeet Anand,
  • Edward Inpent Campal,
  • Kanagaraju Surya,
  • Rajaram Hansda,
  • Muniyasamy Afrith,
  • Manickam Selvaraj,
  • Mohammed A. Assiri,
  • Maibam Malemngamba Meitei,
  • Ulaganathan Arisekar

摘要

Bile acids (BAs) play a crucial role in fish physiology, influencing digestion, lipid metabolism, osmoregulation, and endocrine function. Synthesized in the liver from cholesterol, they facilitate lipid emulsification and absorption in the intestine. Unlike mammals, fish exhibit species-specific variations in bile acid composition, reflecting their diverse evolutionary adaptations and dietary habits. The gut microbiota and environmental factors influence the production of primary and secondary bile acids in fish, thereby affecting their metabolic and physiological functions. Beyond digestion, bile acids act as signalling molecules by modulating nuclear and membrane receptors, such as the Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5), modulating energy metabolism, immune responses, and stress adaptation in aquatic environments. Recent studies suggest that bile acids influence fish growth, reproduction, and disease resistance, making them valuable in aquaculture for improving feed efficiency and health management. Additionally, dietary BA supplementation has shown potential in mitigating lipid peroxidation and enhancing intestinal integrity, particularly under intensive farming conditions. However, excessive accumulation can lead to hepatotoxicity, underscoring the need for a balanced approach to their application in fish nutrition. Advances in analytical methods, particularly liquid chromatography-mass spectrometry (LC–MS), have facilitated a detailed profiling of BAs across fish species, offering insights into their physiological significance and potential biotechnological applications. This review comprehensively analyzes the metabolism, function, and emerging role of BAs in aquaculture, highlighting current research gaps and future directions for optimizing fish health and production. Understanding the dynamics of bile acids in fish can contribute to sustainable aquaculture practices by enhancing nutrient utilization, stress resilience, and disease management strategies.