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<p>Animal models are invaluable for studying biological processes and disease mechanisms. Fish, as vertebrates, share many conserved physiological, anatomical, and molecular features with humans, making them a valuable biological model. Their unique biological characteristics make them easy to manipulate and maintain in laboratory conditions. Also, fish diversity provides many options for choosing the most suitable model for a specific study. The increasing prevalence of microbiota-related diseases has heightened interest in gut microbiota and its impact on health, as gut microbiota is involved in several systems, such as digestive, endocrine, physiological, and immune systems; however, host-microorganism interaction mechanisms are far from being fully described. This review explores the potential of fish models in gut microbiota research, highlighting applications in biomedical and aquaculture sciences.</p>

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Fish as biological models: Implications for gut microbiota research in biomedical and aquaculture sciences

  • 期刊论文

  • 发表日期：

    2025年5月2日

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  • Diana Medina-Félix,
  • Estefanía Garibay-Valdez,
  • Francisco Vargas-Albores,
  • Cinthia Alejandra Olivas-Bernal,
  • Yuniel Mendez-Martínez,
  • Luis Rafael Martínez-Córdova,
  • Marcel Martínez-Porchas

摘要

Animal models are invaluable for studying biological processes and disease mechanisms. Fish, as vertebrates, share many conserved physiological, anatomical, and molecular features with humans, making them a valuable biological model. Their unique biological characteristics make them easy to manipulate and maintain in laboratory conditions. Also, fish diversity provides many options for choosing the most suitable model for a specific study. The increasing prevalence of microbiota-related diseases has heightened interest in gut microbiota and its impact on health, as gut microbiota is involved in several systems, such as digestive, endocrine, physiological, and immune systems; however, host-microorganism interaction mechanisms are far from being fully described. This review explores the potential of fish models in gut microbiota research, highlighting applications in biomedical and aquaculture sciences.