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<p>Stimulation of non-specific immune responses in Nile tilapia by seaweed-based natural compounds is a potential solution for the deterrence of Tilapia Lake Virus (TiLV) outbreaks. The present study investigated the protective and immunostimulatory effects of different seaweed extracts against TiLV. The study deals with hot water extracts of ten seaweeds in total namely <i>Gracilaria edulis, Ulva fasciata, Caulerpa toxifolia, Turbinaria ornata, Enteromorpha compressa, Sargassum wightii, Sargassum ilicifolium, Sargassum muticum, Hynea musciformis</i> and <i>Chaetomorpha aerea</i> collected from the Gulf of Mannar coast of Mandapam and Rameswaram, Tamil Nadu. Among these, extracts of three seaweeds such as <i>S. ilicifolium, U. fasciata,</i> and <i>E. compressa</i> exhibited notable antiviral effects by inhibiting cytopathic effect without cell toxicity in striped snakehead (SSN1) cell line. These seaweed extracts were further incorporated into artificial pellet feed at different concentrations (100, 300 and 500&#xa0;mg/kg). Of which, tilapia fed with diet containing <i>S. ilicifolium</i> at 500&#xa0;mg/kg of feed showed the highest RPS value (58.34%) followed by <i>U. fasciata</i> (50%) and <i>E. compressa</i> (41.67%). Additionally, significant (<i>P</i> &lt; 0.05) improvements in haematological parameters, immunological parameters and immune gene expression were observed in the <i>S. ilicifolium</i>-fed group at 24, 48 and 72&#xa0;h post-infection. The findings highlight <i>S. ilicifolium</i> extract as a natural dietary immunostimulant that enhances the health, productivity and management of TiLV in tilapia farming, promoting a sustainable approach to mitigate disease outbreaks in commercial aquaculture.</p>

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Protective and haemato-immunological effect of seaweed crude extracts against Tilapia Lake Virus (TiLV) in Nile tilapia, Oreochromis niloticus

  • 期刊论文

  • 发表日期：

    2025年1月2日

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  • Kaviyarasu Periyannan,
  • Sivasankar Panchavarnam,
  • Chrisolite Bagthasingh,
  • Subash Palaniappan,
  • Priyadharshini Michael,
  • Mageshkumar Palraj,
  • Mohamed Mansoor Mohaideenpitchai,
  • Selvamagheswaran Muthumariyapan

摘要

Stimulation of non-specific immune responses in Nile tilapia by seaweed-based natural compounds is a potential solution for the deterrence of Tilapia Lake Virus (TiLV) outbreaks. The present study investigated the protective and immunostimulatory effects of different seaweed extracts against TiLV. The study deals with hot water extracts of ten seaweeds in total namely Gracilaria edulis, Ulva fasciata, Caulerpa toxifolia, Turbinaria ornata, Enteromorpha compressa, Sargassum wightii, Sargassum ilicifolium, Sargassum muticum, Hynea musciformis and Chaetomorpha aerea collected from the Gulf of Mannar coast of Mandapam and Rameswaram, Tamil Nadu. Among these, extracts of three seaweeds such as S. ilicifolium, U. fasciata, and E. compressa exhibited notable antiviral effects by inhibiting cytopathic effect without cell toxicity in striped snakehead (SSN1) cell line. These seaweed extracts were further incorporated into artificial pellet feed at different concentrations (100, 300 and 500 mg/kg). Of which, tilapia fed with diet containing S. ilicifolium at 500 mg/kg of feed showed the highest RPS value (58.34%) followed by U. fasciata (50%) and E. compressa (41.67%). Additionally, significant (P < 0.05) improvements in haematological parameters, immunological parameters and immune gene expression were observed in the S. ilicifolium-fed group at 24, 48 and 72 h post-infection. The findings highlight S. ilicifolium extract as a natural dietary immunostimulant that enhances the health, productivity and management of TiLV in tilapia farming, promoting a sustainable approach to mitigate disease outbreaks in commercial aquaculture.