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<p>Programmed cell death has evolved from the classical concept of apoptosis to a diverse repertoire that includes necroptosis, pyroptosis, ferroptosis, cuproptosis, paraptosis, panoptosis, and even the reversal process of anastasis. These pathways have transformed our understanding of health and disease, influencing oncology, neurodegeneration, cardiovascular biology, infection, and immunity. Reflecting this growth, <i>Apoptosis</i> has reached a record Impact Factor of 8.1 in 2024, underscoring both the rising impact of cell death research and the journal’s role as its central forum. This success reflects a community effort of authors, reviewers, and editorial board members, and highlights how programmed cell death continues to shape the future of biology and medicine.</p>

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Death never dies: increasing impact of programmed cell death

  • 期刊论文

  • 发表日期：

    2025年11月22日

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  • Patrycja Nowak-Sliwinska,
  • Arjan W. Griffioen

摘要

Programmed cell death has evolved from the classical concept of apoptosis to a diverse repertoire that includes necroptosis, pyroptosis, ferroptosis, cuproptosis, paraptosis, panoptosis, and even the reversal process of anastasis. These pathways have transformed our understanding of health and disease, influencing oncology, neurodegeneration, cardiovascular biology, infection, and immunity. Reflecting this growth, Apoptosis has reached a record Impact Factor of 8.1 in 2024, underscoring both the rising impact of cell death research and the journal’s role as its central forum. This success reflects a community effort of authors, reviewers, and editorial board members, and highlights how programmed cell death continues to shape the future of biology and medicine.