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<p>Breast cancer ranks first among female malignant tumors and is the largest cancer worldwide. Recently, research on chiral metal-based complexes for cancer treatment has significantly increased. This study synthesized an <i>L</i>-copper(II) complex Cu-1 and a pair of chiral nickel(II) complexes Ni-1 (<i>L</i>-type) and Ni-2 (<i>D</i>-type). The antiproliferative activities of Cu-1, Ni-1, and Ni-2 against female malignant tumor cells (MCF-7, MDA-MB-231, SKOV3, Hela) were evaluated. Among them, the <i>L</i>-type complexes Cu-1 and Ni-1 exhibited superior bioactivity compared to the <i>D</i>-type Ni-2. Further mechanistic studies demonstrated that Cu-1 and Ni-1 could effectively inhibit the growth of MCF-7 cells. Additionally, in vivo experiments in nude mice verified that Cu-1 could exert anti-tumor effects through the synergistic action of multiple pathways. In summary, Cu-1 and Ni-1 possess multiple functions including anti-tumor angiogenesis, anti-inflammatory, apoptosis, and copper-induced death, providing theoretical reference for the development of breast cancer drugs.</p> Graphical abstract <p></p>

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Novel L-type chiral metal(II) complexes inhibit breast cancer growth through synergistic effects of anti-angiogenesis, anti-inflammatory, apoptosis induction and cuproptosis

  • 期刊论文

  • 发表日期：

    2025年7月27日

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  • Nan Jin,
  • Bing-Bing Xu,
  • Hong-Yu Lin,
  • Bing-Li Jiang,
  • Qiao-Ying Yang,
  • Xiu-Ying Qin

摘要

Breast cancer ranks first among female malignant tumors and is the largest cancer worldwide. Recently, research on chiral metal-based complexes for cancer treatment has significantly increased. This study synthesized an L-copper(II) complex Cu-1 and a pair of chiral nickel(II) complexes Ni-1 (L-type) and Ni-2 (D-type). The antiproliferative activities of Cu-1, Ni-1, and Ni-2 against female malignant tumor cells (MCF-7, MDA-MB-231, SKOV3, Hela) were evaluated. Among them, the L-type complexes Cu-1 and Ni-1 exhibited superior bioactivity compared to the D-type Ni-2. Further mechanistic studies demonstrated that Cu-1 and Ni-1 could effectively inhibit the growth of MCF-7 cells. Additionally, in vivo experiments in nude mice verified that Cu-1 could exert anti-tumor effects through the synergistic action of multiple pathways. In summary, Cu-1 and Ni-1 possess multiple functions including anti-tumor angiogenesis, anti-inflammatory, apoptosis, and copper-induced death, providing theoretical reference for the development of breast cancer drugs.

Graphical abstract