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<p>Honeybees are critical pollinators for global agriculture but face numerous threats, notably the ubiquitous devastating ectoparasitic mite <i>Varroa destructor</i>. Using acaricides and other chemicals to control mites not only fosters pesticide resistance but also harms honeybees and contaminates their products, thus sparking growing interest in natural alternatives, particularly essential oils (EOs). In this study, the EO extracted from the camphor leaves (<i>Cinnamomum camphora</i>) was used to investigate its effects on <i>V. destructor</i> and the underlying RNA regulatory mechanisms. The results showed that 27 long non-coding RNAs (lncRNAs) and 305 mRNAs were differentially expressed between the camphor EO-treated and control groups. GO enrichment analysis revealed that the biological processes associated with differential lncRNA expression, in EO-exposed or unexposed <i>V. destructor</i> mites, were primarily related to cellular and metabolic processes. Additionally, the lncRNA-targeted mRNAs in <i>V. destructor</i> mites exhibited upregulated ABC transporter expression post EO exposure; mRNAs regulated by the P53 signaling pathway were also upregulated. These results suggest that camphor leaf EO may affect mite biology by triggering immune responses and disrupting the ability of mites to evade or suppress the immune system of the host. This study provides novel insights into how natural EOs control mites in terms of RNA regulatory networks.</p>

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Gene expression of long non-coding RNAs and messenger RNAs in Varroa destructor mites exposed to essential oil of camphor leaves

  • 期刊论文

  • 发表日期：

    2025年10月20日

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  • Siyi Shen,
  • Meng Li,
  • Tongyu Dong,
  • Kai Xu,
  • Lili Wu,
  • Kang Wang,
  • Defang Niu,
  • Qingsheng Niu,
  • Ting Ji,
  • Zhi Wang,
  • Zheguang Lin

摘要

Honeybees are critical pollinators for global agriculture but face numerous threats, notably the ubiquitous devastating ectoparasitic mite Varroa destructor. Using acaricides and other chemicals to control mites not only fosters pesticide resistance but also harms honeybees and contaminates their products, thus sparking growing interest in natural alternatives, particularly essential oils (EOs). In this study, the EO extracted from the camphor leaves (Cinnamomum camphora) was used to investigate its effects on V. destructor and the underlying RNA regulatory mechanisms. The results showed that 27 long non-coding RNAs (lncRNAs) and 305 mRNAs were differentially expressed between the camphor EO-treated and control groups. GO enrichment analysis revealed that the biological processes associated with differential lncRNA expression, in EO-exposed or unexposed V. destructor mites, were primarily related to cellular and metabolic processes. Additionally, the lncRNA-targeted mRNAs in V. destructor mites exhibited upregulated ABC transporter expression post EO exposure; mRNAs regulated by the P53 signaling pathway were also upregulated. These results suggest that camphor leaf EO may affect mite biology by triggering immune responses and disrupting the ability of mites to evade or suppress the immune system of the host. This study provides novel insights into how natural EOs control mites in terms of RNA regulatory networks.