<p>Aquaculture is a rapidly growing industry that plays a crucial role in meeting the global demand for seafood. However, intensive aquacultural farming practices present significant challenges, including disease outbreaks, environmental pollution, and the development of antibiotic resistance. In recent years, the use of plant-derived bioactive compounds has emerged as a promising alternative approach to address these challenges. Plant bioactive compounds demonstrate diverse therapeutic and regulatory properties that make them particularly suitable for aquaculture applications. This review article aims to provide a comprehensive overview of the potential and application of plant bioactive compounds in aquaculture. It categorizes major classes of these compounds and evaluates their benefits in enhancing fish health, growth performance, and water quality. The review also discusses the challenges and limitations associated with the use of plant bioactive compounds in aquaculture while identifying critical knowledge gaps that require further investigation. By summarizing existing research and identifying future research directions, this article provides essential guidance for researchers, aquaculture professionals, and stakeholders pursuing the sustainable and innovative use of plant-based solutions in aquaculture farming practices.</p>