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Objective <p>To determine the biomechanical properties of the central corneal region under intraocular pressure (IOP) and to develop an accurate method for predicting the corresponding responses.</p> Methods <p>In the rabbit corneal inflation test, a calculation method for the biomechanical properties in the thickness direction of the cornea was proposed. The corresponding stress–strain relationship was obtained from the change in the central corneal thickness and IOP. Finite element analysis (FEA) was utilized to predict the biomechanical responses of the central corneal region under IOP using the derived stress–strain relationship. The FEA predictions using the stress–strain relationships derived from&#xa0;the&#xa0;uniaxial tensile test and optical coherence elastography (OCE) were also conducted for comparison.</p> Results <p>The prediction accuracy of the FEA based on the inflation test was evaluated against OCE (in-plane), OCE (out-of-plane), and uniaxial tensile test. Compared to these methods, the maximum deviation of the apex displacement prediction based on the inflation test decreased by 73.2, 88.4, and 64.4%, respectively, and the maximum deviation of the central curvature prediction decreased by 89.2, 30.7, and 49.7%, respectively.</p> Conclusion <p>The stress–strain relationship in the thickness direction of the cornea can provide the most accurate prediction result of the corneal biomechanical responses under IOP. The inflation test-based method proposed can serve as an accurate tool for biomechanical characterization of the central corneal region.</p>

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Biomechanical Characterization of Central Corneal Region Using Inflation Test and its Application to Predicting Central Corneal Response Under Intraocular Pressure

  • 期刊论文

  • 发表日期：

    2025年11月6日

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  • Zimeng Zhou,
  • Honghao Wang,
  • Ying Zhang,
  • Haijun Lv,
  • Zhuoyu Zhang,
  • Huaming Li,
  • Xiuli Liu,
  • Tingwei Quan,
  • Xiaohua Lv,
  • Shaoqun Zeng

摘要

Objective

To determine the biomechanical properties of the central corneal region under intraocular pressure (IOP) and to develop an accurate method for predicting the corresponding responses.

Methods

In the rabbit corneal inflation test, a calculation method for the biomechanical properties in the thickness direction of the cornea was proposed. The corresponding stress–strain relationship was obtained from the change in the central corneal thickness and IOP. Finite element analysis (FEA) was utilized to predict the biomechanical responses of the central corneal region under IOP using the derived stress–strain relationship. The FEA predictions using the stress–strain relationships derived from the uniaxial tensile test and optical coherence elastography (OCE) were also conducted for comparison.

Results

The prediction accuracy of the FEA based on the inflation test was evaluated against OCE (in-plane), OCE (out-of-plane), and uniaxial tensile test. Compared to these methods, the maximum deviation of the apex displacement prediction based on the inflation test decreased by 73.2, 88.4, and 64.4%, respectively, and the maximum deviation of the central curvature prediction decreased by 89.2, 30.7, and 49.7%, respectively.

Conclusion

The stress–strain relationship in the thickness direction of the cornea can provide the most accurate prediction result of the corneal biomechanical responses under IOP. The inflation test-based method proposed can serve as an accurate tool for biomechanical characterization of the central corneal region.