<p>Congenital lung malformations (CLM) encompass cystic, hyperinflated or solid pulmonary lesions which are often detected prenatally. Despite their benign nature these malformations can be clinically relevant as they cause complications, such as respiratory distress, recurrent infections or, in rare cases, malignant transformation. The objective of this review is to summarize the most important subtypes of CLM, their diagnostics, therapeutic indications and possible complications. The study provides a&#xa0;comprehensive overview of the main CLM forms, including congenital pulmonary airway malformation (CPAM), pulmonary sequestration, bronchogenic cysts, congenital lobar overinflation (CLO) and bronchial atresia based on the current literature and clinical experience. Imaging techniques, particularly magnetic resonance imaging (MRI) and computed tomography (CT), are evaluated for their diagnostic efficacy. The incidence of CLM is approximately&#xa0;1 in 2500 live births, with respiratory distress and recurrent infections being the most common clinical manifestations. Although CPAM and pulmonary sequestration often show cystic or solid masses, bronchogenic cysts result from abnormal embryonic foregut budding. Sequestration is characterized by a systemic arterial supply. Imaging plays a central role for the diagnostics and surgical planning. Surgical resection is indicated in symptomatic cases or when there is an increased risk of infection or malignancy. The CLM requires an interdisciplinary clarification and individual treatment planning. Prophylactic resection can also be meaningful in asymptomatic patients to avoid long-term complications. New MRI techniques provide a radiation-free alternative to CT.</p>

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Kongenitale Lungenfehlbildungen und ihre Konsequenzen

  • Daniel Gräfe,
  • Martin Lacher,
  • Franz Wolfgang Hirsch

摘要

Congenital lung malformations (CLM) encompass cystic, hyperinflated or solid pulmonary lesions which are often detected prenatally. Despite their benign nature these malformations can be clinically relevant as they cause complications, such as respiratory distress, recurrent infections or, in rare cases, malignant transformation. The objective of this review is to summarize the most important subtypes of CLM, their diagnostics, therapeutic indications and possible complications. The study provides a comprehensive overview of the main CLM forms, including congenital pulmonary airway malformation (CPAM), pulmonary sequestration, bronchogenic cysts, congenital lobar overinflation (CLO) and bronchial atresia based on the current literature and clinical experience. Imaging techniques, particularly magnetic resonance imaging (MRI) and computed tomography (CT), are evaluated for their diagnostic efficacy. The incidence of CLM is approximately 1 in 2500 live births, with respiratory distress and recurrent infections being the most common clinical manifestations. Although CPAM and pulmonary sequestration often show cystic or solid masses, bronchogenic cysts result from abnormal embryonic foregut budding. Sequestration is characterized by a systemic arterial supply. Imaging plays a central role for the diagnostics and surgical planning. Surgical resection is indicated in symptomatic cases or when there is an increased risk of infection or malignancy. The CLM requires an interdisciplinary clarification and individual treatment planning. Prophylactic resection can also be meaningful in asymptomatic patients to avoid long-term complications. New MRI techniques provide a radiation-free alternative to CT.