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<p>We investigate the proliferation of <i>Klebsiella pneumoniae</i> in macrophages, after being stressed inside microchannels in different fluidic media. In the present study, we consider three fluidic mediums, a nutrient deficit and a nutrient rich media along with MilliQ water to assess whether bacteria exhibit higher virulence in presence of nutrients. Our results suggest that bacterial virulence is weakly dependent on the fluidic nutrients for the given period of stressing time and magnitude. Rather, we observe that the intracellular proliferation of stressed bacterial cells is highly sensitive to the shear rate. The study finds importance in optimizing bioreactor designs, medical implant and organ-on-a-chip devices.</p>

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Fluidic stresses alter bacterial virulence: the effect of different physiological fluids

  • 期刊论文

  • 发表日期：

    2026年4月4日

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  • Siddhant Jain,
  • Anmol Singh,
  • Shafinaz Tayaba,
  • Abhishek Biswas,
  • Dipshikha Chakravortty,
  • Saptarshi Basu

摘要

We investigate the proliferation of Klebsiella pneumoniae in macrophages, after being stressed inside microchannels in different fluidic media. In the present study, we consider three fluidic mediums, a nutrient deficit and a nutrient rich media along with MilliQ water to assess whether bacteria exhibit higher virulence in presence of nutrients. Our results suggest that bacterial virulence is weakly dependent on the fluidic nutrients for the given period of stressing time and magnitude. Rather, we observe that the intracellular proliferation of stressed bacterial cells is highly sensitive to the shear rate. The study finds importance in optimizing bioreactor designs, medical implant and organ-on-a-chip devices.