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Purpose <p>To measure embryonic nuchal translucency (NT) thickness and ductus venosus (DV) blood flow indices using transvaginal two-dimensional sonography and Doppler ultrasound at 8–10 + 6&#xa0;weeks.</p> Methods <p>Transvaginal scans were performed for 149 normal and three abnormal embryos (trisomy 18 with ventricular septal defect (VSD), tricuspid insufficiency (TR), and intrauterine fetal death with trisomy 21) at 8–10 + 6&#xa0;weeks. NT thickness, S wave (cm/s), D wave (cm/s), “a” wave (cm/s), S/a, pulsatility index (PI), and resistance index (RI) of DV were measured, and reference values for each parameter were determined.</p> Results <p>NT, S, D, S/a, PI, and RI increased linearly with advancing gestation (<i>p</i> &lt; 0.01). The ‘a’ (mean, 5.55&#xa0;cm/s; SD, 1.8&#xa0;cm/s) value was constant at 8–10 + 6&#xa0;weeks of gestation. There were significant linear correlations between NT, S, D, S/a, PI, and RI, and crown–rump length (CRL) (<i>p</i> &lt; 0.01). The “a” value remained unchanged with increasing CRL during this period. NT thickness (2.8&#xa0;mm) in the trisomy 18 patient with VSD was high at 10 + 6&#xa0;weeks, and reversed “a” wave was evident in the patient with TR at 10 + 1&#xa0;weeks. In a fetus with intrauterine fetal death with trisomy 21 at 11&#xa0;weeks and 6&#xa0;days, NT thickness was 2.1&#xa0;mm, and reversed DV flow was noted at 9&#xa0;weeks and 6&#xa0;days.</p> Conclusion <p>Our results provide reference values for NT thickness and DV flow parameters, which may advance our understanding of embryonic growth and promote earlier prenatal diagnosis of chromosome abnormalities and/or cardiac anomalies before 11&#xa0;weeks.</p>

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Embryonic reference values for nuchal translucency thickness and ductus venosus blood flow at 8–10 + 6 gestational weeks

  • 期刊论文

  • 发表日期：

    2026年5月8日

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  • Toshiyuki Hata,
  • Miyu Konishi,
  • Aya Koyanagi,
  • Yasunari Miyagi,
  • Takahito Miyake,
  • Nobuhiko Hayashi

摘要

Purpose

To measure embryonic nuchal translucency (NT) thickness and ductus venosus (DV) blood flow indices using transvaginal two-dimensional sonography and Doppler ultrasound at 8–10 + 6 weeks.

Methods

Transvaginal scans were performed for 149 normal and three abnormal embryos (trisomy 18 with ventricular septal defect (VSD), tricuspid insufficiency (TR), and intrauterine fetal death with trisomy 21) at 8–10 + 6 weeks. NT thickness, S wave (cm/s), D wave (cm/s), “a” wave (cm/s), S/a, pulsatility index (PI), and resistance index (RI) of DV were measured, and reference values for each parameter were determined.

Results

NT, S, D, S/a, PI, and RI increased linearly with advancing gestation (p < 0.01). The ‘a’ (mean, 5.55 cm/s; SD, 1.8 cm/s) value was constant at 8–10 + 6 weeks of gestation. There were significant linear correlations between NT, S, D, S/a, PI, and RI, and crown–rump length (CRL) (p < 0.01). The “a” value remained unchanged with increasing CRL during this period. NT thickness (2.8 mm) in the trisomy 18 patient with VSD was high at 10 + 6 weeks, and reversed “a” wave was evident in the patient with TR at 10 + 1 weeks. In a fetus with intrauterine fetal death with trisomy 21 at 11 weeks and 6 days, NT thickness was 2.1 mm, and reversed DV flow was noted at 9 weeks and 6 days.

Conclusion

Our results provide reference values for NT thickness and DV flow parameters, which may advance our understanding of embryonic growth and promote earlier prenatal diagnosis of chromosome abnormalities and/or cardiac anomalies before 11 weeks.