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<p>Zoonotic diseases are increasingly affecting global health, making it crucial to understand viral dynamics in wildlife reservoirs like bats. Bats are well-established coronavirus reservoirs, and their proximity to human habitats in France raises concerns about zoonotic transmission. This study investigates the prevalence, diversity, and phylogenetic relationships of coronaviruses in bats from the Camargue and Eastern Provence, two ecologically distinct regions. A total of 785 bat guano samples were collected non-invasively, with 154 (19.6%) testing positive for coronavirus RNA, among the highest infection rates observed in European studies. Camargue samples were entirely from <i>Pipistrellus</i> bats, with a prevalence of 20.1%, while Provence showed greater genus diversity and prevalence ranging from 1.3% to 35.6%. Phylogenetic analysis identified <i>Alphacoronaviruses</i> in four subgenera: <i>Nyctacovirus</i>, <i>Myotacovirus</i>, <i>Decacovirus</i>, and <i>Minunacovirus</i>, alongside unclassified sequences. No coronavirus related to human-infecting strains (e.g., HCoV-229E) was detected. However, the combination of high prevalence, proximity to humans, and potential for host-switching led to the investigation of coronavirus infection in bats, a topic with limited data in France. These findings highlight the ecological role of bats and the importance of continuous viral monitoring, filling a gap in knowledge about coronavirus circulation in European bat populations.</p>

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High Prevalence and Diversity of Alphacoronaviruses in Bats in Southern France

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月21日

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  • Océane Rieu,
  • Anaïs Dufau,
  • Jordan Meliani,
  • Lionel Brazier,
  • Marion Vittecoq,
  • Carole Leray,
  • Anthony Olivier,
  • Emmanuel Cosson,
  • Frédéric Thomas,
  • Eric Leroy,
  • Illich Mombo

摘要

Zoonotic diseases are increasingly affecting global health, making it crucial to understand viral dynamics in wildlife reservoirs like bats. Bats are well-established coronavirus reservoirs, and their proximity to human habitats in France raises concerns about zoonotic transmission. This study investigates the prevalence, diversity, and phylogenetic relationships of coronaviruses in bats from the Camargue and Eastern Provence, two ecologically distinct regions. A total of 785 bat guano samples were collected non-invasively, with 154 (19.6%) testing positive for coronavirus RNA, among the highest infection rates observed in European studies. Camargue samples were entirely from Pipistrellus bats, with a prevalence of 20.1%, while Provence showed greater genus diversity and prevalence ranging from 1.3% to 35.6%. Phylogenetic analysis identified Alphacoronaviruses in four subgenera: Nyctacovirus, Myotacovirus, Decacovirus, and Minunacovirus, alongside unclassified sequences. No coronavirus related to human-infecting strains (e.g., HCoV-229E) was detected. However, the combination of high prevalence, proximity to humans, and potential for host-switching led to the investigation of coronavirus infection in bats, a topic with limited data in France. These findings highlight the ecological role of bats and the importance of continuous viral monitoring, filling a gap in knowledge about coronavirus circulation in European bat populations.