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Background <p>Barrett’s mucosa in the remnant esophagus (BMRE) is often identified after gastric pull-up reconstruction after esophagectomy. This study aimed to determine the clinical characteristics of BMRE and the factors that affect the development of BMRE.</p> Methods <p>The characteristics of BMRE and factors affecting its occurrence were studied in patients with subtotal esophagectomy and gastric pull-up reconstruction who survived at least 3&#xa0;years after esophageal cancer surgery and who were evaluated by endoscopy.</p> Results <p>A total of 187 eligible patients were identified, BMRE was found in 105 (56.1%) patients. The mean time from esophagectomy to confirmation of BMRE was 667.4&#xa0;days. Ninety-four (89.5%) patients had ultra-short segment BMRE, nine (8.6%) had short segment BMRE, and one (1.0%) had long segment BMRE. Patients with BMRE were significantly younger than those without BMRE (<i>p</i> &lt; 0.001). The incidence of gastro-esophageal reflux disease (GERD) and the frequency of severe GERD (Grade C and D) were significantly higher in the BMRE-positive group than in the BMRE-negative group (both <i>p</i> &lt; 0.001). BMRE was less frequent in patients who were taking potassium-competitive acid blockers than in those who were not (<i>p</i> = 0.047). A logistic regression analysis showed that a younger age (≤ 67&#xa0;years) (<i>p</i> = 0.002) and GERD (<i>p</i> &lt; 0.001) were independent risk factors for BMRE.</p> Conclusions <p>BMRE frequently occurs in patients with gastric pull-up reconstruction. The presence of GERD at a young age and more severe GERD increase the incidence of BMRE, and the administration of potassium-competitive acid blockers may decrease BMRE.</p>

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Clinical features of Barrett’s mucosa arising in the remnant esophagus after subtotal esophagectomy and esophago-gastric anastomosis for esophageal cancer

  • 期刊论文

  • 发表日期：

    2025年9月10日

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  • Masanobu Nakajima,
  • Masatoshi Nakagawa,
  • Junki Fujita,
  • Shuhei Takise,
  • Takahiro Ochiai,
  • Yu Ueta,
  • Masaki Yoshimatsu,
  • Noboru Inoue,
  • Hiroto Muroi,
  • Shinji Morita,
  • Kazuyuki Kojima

摘要

Background

Barrett’s mucosa in the remnant esophagus (BMRE) is often identified after gastric pull-up reconstruction after esophagectomy. This study aimed to determine the clinical characteristics of BMRE and the factors that affect the development of BMRE.

Methods

The characteristics of BMRE and factors affecting its occurrence were studied in patients with subtotal esophagectomy and gastric pull-up reconstruction who survived at least 3 years after esophageal cancer surgery and who were evaluated by endoscopy.

Results

A total of 187 eligible patients were identified, BMRE was found in 105 (56.1%) patients. The mean time from esophagectomy to confirmation of BMRE was 667.4 days. Ninety-four (89.5%) patients had ultra-short segment BMRE, nine (8.6%) had short segment BMRE, and one (1.0%) had long segment BMRE. Patients with BMRE were significantly younger than those without BMRE (p < 0.001). The incidence of gastro-esophageal reflux disease (GERD) and the frequency of severe GERD (Grade C and D) were significantly higher in the BMRE-positive group than in the BMRE-negative group (both p < 0.001). BMRE was less frequent in patients who were taking potassium-competitive acid blockers than in those who were not (p = 0.047). A logistic regression analysis showed that a younger age (≤ 67 years) (p = 0.002) and GERD (p < 0.001) were independent risk factors for BMRE.

Conclusions

BMRE frequently occurs in patients with gastric pull-up reconstruction. The presence of GERD at a young age and more severe GERD increase the incidence of BMRE, and the administration of potassium-competitive acid blockers may decrease BMRE.