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Purpose <p>To compare physician-assessed and patient-reported outcomes quantified with the Japanese Ocular Surface Disease Index (J-OSDI) following the treatment of bacterial blepharitis and to evaluate the utility of the J-OSDI.</p> Study design <p>Multicenter prospective observational study.</p> Methods <p>Physicians assessed symptoms and findings, calculating clinical total scores at baseline (T0), 7&#xa0;(T1) and 14 (T2) days post-treatment with 1% azithromycin ophthalmic solution, and 1 month after discontinuation (T3). Patients self-reported symptoms using the J-OSDI at these times. The J-OSDI score trends and differences in temporal changes between the J-OSDI and clinical total scores were analyzed by use of a linear mixed-effects model.</p> Results <p>Forty-six eyes (46 patients; mean age, 71.8 years) were studied. The J-OSDI scores decreased significantly post-treatment for all the patients, with similar trends for both anterior and posterior blepharitis. For all the patients, the slope difference between the J-OSDI and clinical total scores was not significant in the T0–T1 period (<i>P</i> = .219), meaning that the J-OSDI scores reflected the clinical results, whereas it was significant in the T1–T2 (<i>P</i> = .004) and T2–T3 (<i>P</i> &lt;.001) periods. The within-subject correlation between the 2 scores was 0.525 (95% CI 0.401–0.631). For anterior blepharitis, the slope differences were significant across all the periods, but for posterior blepharitis, no significant differences were observed in the T0–T1 or T1–T2 (<i>P</i> = .205, 0.06, respectively) periods, although significant differences were noted in the T2–T3 period (<i>P</i> = .018).</p> Conclusion <p>The J-OSDI trajectory often diverges from physician-rated changes. Whilst the J-OSDI does not assess treatment response in anterior blepharitis, it may be partially reflective of improvement in posterior blepharitis.</p>

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Comparison of physician-assessed and patient-reported outcomes of using azithromycin eye drops in the treatment of bacterial blepharitis

  • 期刊论文

  • 发表日期：

    2026年5月8日

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  • Takashi Suzuki,
  • Ryohei Nejima,
  • Tomoyuki Inoue,
  • Yuichi Kaji,
  • Takaaki Hattori,
  • Saichi Hoshi,
  • Daisuke Todokoro,
  • Hiroshi Eguchi,
  • Michikazu Nakai,
  • Yoshitsugu Inoue

摘要

Purpose

To compare physician-assessed and patient-reported outcomes quantified with the Japanese Ocular Surface Disease Index (J-OSDI) following the treatment of bacterial blepharitis and to evaluate the utility of the J-OSDI.

Study design

Multicenter prospective observational study.

Methods

Physicians assessed symptoms and findings, calculating clinical total scores at baseline (T0), 7 (T1) and 14 (T2) days post-treatment with 1% azithromycin ophthalmic solution, and 1 month after discontinuation (T3). Patients self-reported symptoms using the J-OSDI at these times. The J-OSDI score trends and differences in temporal changes between the J-OSDI and clinical total scores were analyzed by use of a linear mixed-effects model.

Results

Forty-six eyes (46 patients; mean age, 71.8 years) were studied. The J-OSDI scores decreased significantly post-treatment for all the patients, with similar trends for both anterior and posterior blepharitis. For all the patients, the slope difference between the J-OSDI and clinical total scores was not significant in the T0–T1 period (P = .219), meaning that the J-OSDI scores reflected the clinical results, whereas it was significant in the T1–T2 (P = .004) and T2–T3 (P <.001) periods. The within-subject correlation between the 2 scores was 0.525 (95% CI 0.401–0.631). For anterior blepharitis, the slope differences were significant across all the periods, but for posterior blepharitis, no significant differences were observed in the T0–T1 or T1–T2 (P = .205, 0.06, respectively) periods, although significant differences were noted in the T2–T3 period (P = .018).

Conclusion

The J-OSDI trajectory often diverges from physician-rated changes. Whilst the J-OSDI does not assess treatment response in anterior blepharitis, it may be partially reflective of improvement in posterior blepharitis.