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Purpose <p>To investigate the effect of preservative-containing and preservative-free latanoprost eyedrops on dry eye symptoms and matrix metalloproteinase 9 expression in untreated open-angle glaucoma patients.</p> Study design <p>Prospective</p> Methods <p>Treatment-naïve open-angle glaucoma patients were randomly assigned to either preservative-containing or preservative-free latanoprost groups. The ocular surface disease index score, Schirmer test, tear break up time, corneal staining score, and matrix metalloproteinase 9 expression in tears were prospectively compared before and at 1 and 3 months after drug instillation.</p> Results <p>Ocular surface disease index score, Schirmer’s test, tear break up time, corneal staining score, and matrix metalloproteinase 9 expression levels did not significantly differ between the two groups before drug instillation. After 3 months, the preservative-free latanoprost group exhibited a significantly longer tear break up time and improved corneal staining score. The proportion of patients with positive matrix metalloproteinase 9 in tears was lower in the preservative-free group, although this difference was not statistically significant (75.0% vs. 62.5%, <i>P</i> = 0.118).</p> Conclusion <p>Compared with preservative-containing latanoprost, the preservative-free preparation led to improved tear break up time and a potential reduction in positive matrix metalloproteinase 9 expression after 3 months in untreated open-angle glaucoma patients.</p>

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A prospective, randomized study comparing the effects of preservative-free latanoprost and preserved latanoprost eyedrops on MMP-9 expression and ocular surface disease index in glaucoma patients

  • 期刊论文

  • 发表日期：

    2026年2月25日

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  • Edward Kang,
  • Ji-Hye Park,
  • Chungkwon Yoo,
  • Yong Yeon Kim

摘要

Purpose

To investigate the effect of preservative-containing and preservative-free latanoprost eyedrops on dry eye symptoms and matrix metalloproteinase 9 expression in untreated open-angle glaucoma patients.

Study design

Prospective

Methods

Treatment-naïve open-angle glaucoma patients were randomly assigned to either preservative-containing or preservative-free latanoprost groups. The ocular surface disease index score, Schirmer test, tear break up time, corneal staining score, and matrix metalloproteinase 9 expression in tears were prospectively compared before and at 1 and 3 months after drug instillation.

Results

Ocular surface disease index score, Schirmer’s test, tear break up time, corneal staining score, and matrix metalloproteinase 9 expression levels did not significantly differ between the two groups before drug instillation. After 3 months, the preservative-free latanoprost group exhibited a significantly longer tear break up time and improved corneal staining score. The proportion of patients with positive matrix metalloproteinase 9 in tears was lower in the preservative-free group, although this difference was not statistically significant (75.0% vs. 62.5%, P = 0.118).

Conclusion

Compared with preservative-containing latanoprost, the preservative-free preparation led to improved tear break up time and a potential reduction in positive matrix metalloproteinase 9 expression after 3 months in untreated open-angle glaucoma patients.