Scholarlink

<p>Cerebral toxoplasmosis is a&#xa0;form of encephalitis caused by <i>Toxoplasma gondii</i>. It typically occurs in immunocompromised individuals and is rarely observed in patients with B‑cell lymphoma. The first two patients of this case series, both previously diagnosed with peripheral B‑cell lymphoma, presented with new-onset neurological symptoms and cerebral mass lesions. Laboratory results indicated latent infection with <i>T.&#xa0;gondii, </i>but the findings in cerebrospinal fluid were unspecific One patient underwent brain biopsy, thereby confirming the diagnosis histologically, while the second patient was classified as having probable cerebral toxoplasmosis. Both patients were treated with pyrimethamine and sulfadiazine, leading to clinical and radiological improvement within weeks. To highlight the diagnostic pitfalls of cerebral toxoplasmosis, we included a&#xa0;third patient in the case series who presented with a&#xa0;cerebral metastasis of peripheral diffuse large B‑cell lymphoma. Additionally, we performed a&#xa0;comprehensive literature review on cerebral toxoplasmosis in patients with peripheral B‑cell lymphoma.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Cerebral toxoplasmosis in patients with peripheral B-cell lymphoma

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月23日

查看全文
  • Thomas Pass,
  • Raphael Reinecke,
  • Gertraud Heinz,
  • Stefan Oberndorfer

摘要

Cerebral toxoplasmosis is a form of encephalitis caused by Toxoplasma gondii. It typically occurs in immunocompromised individuals and is rarely observed in patients with B‑cell lymphoma. The first two patients of this case series, both previously diagnosed with peripheral B‑cell lymphoma, presented with new-onset neurological symptoms and cerebral mass lesions. Laboratory results indicated latent infection with T. gondii, but the findings in cerebrospinal fluid were unspecific One patient underwent brain biopsy, thereby confirming the diagnosis histologically, while the second patient was classified as having probable cerebral toxoplasmosis. Both patients were treated with pyrimethamine and sulfadiazine, leading to clinical and radiological improvement within weeks. To highlight the diagnostic pitfalls of cerebral toxoplasmosis, we included a third patient in the case series who presented with a cerebral metastasis of peripheral diffuse large B‑cell lymphoma. Additionally, we performed a comprehensive literature review on cerebral toxoplasmosis in patients with peripheral B‑cell lymphoma.