Scholarlink

<p>The big data derived from major international collaborations now makes it possible to validate findings from traditional national patient cohorts in order to demonstrate consistency. We compared findings from <i>CBL</i>-mutated patients in the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) with those in the CMML cohort recorded in cBIOPORTAL. <i>CBL</i> mutations were linked to shorter survival in the ABCMML cohort but not in the cBioPortal cohort. In neither cohort was there an association between AML-free survival and <i>CBL</i> mutations. Elevated leukocyte levels were observed in patients with <i>CBL</i> mutations in both cohorts. In neither cohort did hemoglobin values, platelet values, and circulating blast levels differ between patients with <i>CBL</i> mutations and those without. Data validation using two independent CMML cohorts ensures the quality standards for clinical decision-making.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Characteristics of CBL-mutated patients with chronic myelomonocytic leukemia in a national (ABCMML) and an international cohort (cBIOPORTAL)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月26日

查看全文
  • Alexandra Plötzeneder,
  • Klaus Geissler

摘要

The big data derived from major international collaborations now makes it possible to validate findings from traditional national patient cohorts in order to demonstrate consistency. We compared findings from CBL-mutated patients in the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) with those in the CMML cohort recorded in cBIOPORTAL. CBL mutations were linked to shorter survival in the ABCMML cohort but not in the cBioPortal cohort. In neither cohort was there an association between AML-free survival and CBL mutations. Elevated leukocyte levels were observed in patients with CBL mutations in both cohorts. In neither cohort did hemoglobin values, platelet values, and circulating blast levels differ between patients with CBL mutations and those without. Data validation using two independent CMML cohorts ensures the quality standards for clinical decision-making.