<p>A&#xa0;field experiment was conducted from the periods 2016–2017 to 2017–2018 in the Haringhata block of Nadia District, West Bengal, India, to develop effective integrated nutrient management (INM) strategies for improving the yield and quality of guava and soil health. This study was performed on guava cv. ‘Allahabad Safeda’ that was fertilized with ten different nutrient management treatments comprising recommended doses of fertilizer (RDFs) of different compositions—(N (nitrogen):P (phosphorus):K (potassium): 260:320:260 g plant⁻¹ year⁻¹); farmyard manure (FYM), mustard cake, and biofertilizer mixture (<i>Azospirillum</i> + phosphorus-solubilizing bacteria + potassium-mobilizing bacteria)—with three replicates to fit a&#xa0;randomized block design (RBD). The major growth parameters, such as plant height, basal girth, and canopy volume, significantly improved when the plants received 75% RDF_NPK + 15 kg FYM + 3 kg mustard cake + 100 g (<i>Azospirillum</i> + phosphorus-solubilizing bacteria + potassium-mobilizing bacteria), and the same plants resulted in 32.82% less fruit drop than the control, resulting in the highest fruit retention (63.53%) and maximum yield (51.56 kg tree⁻¹). In terms of fruit yield, the results showed the highest average fresh and dry weights; the maximum volume was also obtained from the same treatment. The application of 75% RDF_NPK + 15 kg FYM + 3 kg mustard cake + 100 g (<i>Azospirillum</i> + phosphorus-solubilizing bacteria + potassium-mobilizing bacteria) yielded the highest total soluble solids (TSS) of 12.32°Brix with less titratable acidity (0.52%) and the maximum concentration of ascorbic acid (181.35 mg 100 g⁻¹) and phenol and pectin contents. Guava plants that received the same treatment achieved maximum values for most of the leaf macronutrients, i.e., leaf P and&#xa0;K (0.30% and 1.54%, respectively); most of the chlorophyll fractions were both in the fruit peel and leaf as well as in the fruit beta-carotene content (1.51 mg 100 g⁻¹). The soil in the RDF_NPK + 15 kg FYM + 3 kg mustard cake + 100 g treatment (<i>Azospirillum</i> + phosphorus-solubilizing bacteria + potassium-mobilizing bacteria) recorded the highest electrical conductivity (EC); organic carbon; and maximum N, P, and K contents, which were on par with the values obtained in the 75% RDF_NPK + 15 kg FYM + 3 kg mustard cake + 100 g treatment (<i>Azospirillum</i> + phosphorus-solubilizing bacteria + potassium-mobilizing bacteria). Hence, from these results, it may be recommended that the integrated treatment of 75% RDF_NPK + 15 kg FYM + 3 kg mustard cake + 100 g (<i>Azospirillum</i> + phosphorus-solubilizing bacteria + potassium-mobilizing bacteria) is most effective for increasing production and quality of guava (cv. ‘Allahabad Safeda’) maintaining the optimum soil fertility status in new alluvial zones of West Bengal.</p>