Scholarlink

<p>Flupyradifurone, a next-generation butenolide insecticide, is widely used for managing piercing-sucking pests and is considered a safer alternative to neonicotinoids due to its low toxicity to mammals and pollinators. However, potential side effects on beneficial predators, which are essential for sustainable pest suppression and integrated pest management (IPM), remain poorly understood. Here, we combined life-history assays, behavioral analyses, and transcriptomic profiling to assess acute and sublethal effects of flupyradifurone on the seven-spotted lady beetle (<i>Coccinella septempunctata</i>), a key aphid predator, across two generations. While acute toxicity was low (hazard quotient &lt; 2), sublethal exposure caused significant fitness costs, including delayed development, reduced body weight, suppressed fecundity and egg hatchability, and impaired predation efficiency. Transgenerational effects included delayed oviposition and altered feeding dynamics in offspring. Transcriptomic analysis revealed 4,934 differentially expressed genes, including those linked to detoxification (cytochrome P450s), reproduction (vitellogenin), and feeding (gustatory receptors), providing mechanistic insights into observed phenotypes. Our results demonstrate that flupyradifurone, despite low acute risk, can substantially compromise predator function and ecosystem services. These findings align with recent EFSA recommendations to incorporate chronic, sublethal, and species-specific endpoints into pesticide risk assessments and offer critical evidence to refine biosafety frameworks and optimize IPM strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Integrating physiology, behavior, and transcriptomics to refine pesticide risk assessment: the case of flupyradifurone and Coccinella septempunctata

  • 期刊论文

  • 发表日期：

    2026年3月14日

查看全文
  • Yuxin Dong,
  • Yajie Zhang,
  • Boyang An,
  • Wenqiu Yuan,
  • Guy Smagghe,
  • Qiuju Qin,
  • Yunzhuan He,
  • Da Wang

摘要

Flupyradifurone, a next-generation butenolide insecticide, is widely used for managing piercing-sucking pests and is considered a safer alternative to neonicotinoids due to its low toxicity to mammals and pollinators. However, potential side effects on beneficial predators, which are essential for sustainable pest suppression and integrated pest management (IPM), remain poorly understood. Here, we combined life-history assays, behavioral analyses, and transcriptomic profiling to assess acute and sublethal effects of flupyradifurone on the seven-spotted lady beetle (Coccinella septempunctata), a key aphid predator, across two generations. While acute toxicity was low (hazard quotient < 2), sublethal exposure caused significant fitness costs, including delayed development, reduced body weight, suppressed fecundity and egg hatchability, and impaired predation efficiency. Transgenerational effects included delayed oviposition and altered feeding dynamics in offspring. Transcriptomic analysis revealed 4,934 differentially expressed genes, including those linked to detoxification (cytochrome P450s), reproduction (vitellogenin), and feeding (gustatory receptors), providing mechanistic insights into observed phenotypes. Our results demonstrate that flupyradifurone, despite low acute risk, can substantially compromise predator function and ecosystem services. These findings align with recent EFSA recommendations to incorporate chronic, sublethal, and species-specific endpoints into pesticide risk assessments and offer critical evidence to refine biosafety frameworks and optimize IPM strategies.