Objective Elevated kurtosis values have been observed in subcortical grey matter structures of patients with neurodegenerative diseases. Here, we examined relationships between iron measures and kurtosis in iron-rich subcortical grey matter structures.Please check and confirm the affiliation 4 for the author "Xiaoping P. Hu".Affiliation 4 for Xiaoping P. Hu was incorrect since he is not associated with that department. We have removed this affiliation.Thanks!  Materials and methods Multi-shell diffusion and multi-echo gradient echo acquisitions were used to derive mean kurtosis and iron measures (R2* and magnetic susceptibility), respectively, in subcortical grey matter nuclei and white matter tracts in a discovery cohort (110 healthy older and 63 younger adults) and replication cohort (72 healthy older adults).Please confirm if the author names are presented accurately and in the correct sequence (Ilana J. Bennett and Xiaoping P. Hu). Also, kindly confirm the details in the metadata are correct.Thanks for asking. We've checked and the names are presented accurately and in the correct sequence. We have corrected some details in the metadata - adding an affiliation to Murphy Shao (Department of Physics) and removing the Materials Science and Engineering affiliation for Xiaoping P. Hu.Is it possible to add an orcid id for Vala Masjedizadeh? His Orcid ID is  0009-0009-3692-2553Everything else looks okay Results Iron-rich grey matter regions exhibited higher mean kurtosis, R2, and magnetic susceptibility and white matter regions had lower mean kurtosis in the older adult group from the discovery cohort. In both cohorts, mean kurtosis was significantly correlated with R2 and magnetic susceptibility in iron-rich grey matter nuclei. No association was seen between signal-to-noise ratio and mean kurtosis in any grey matter region, indicating that the increase in mean kurtosis was not due to reduced signal-to-noise. As keywords are mandatory for this journal, please provide 3-6 keywords.I'm not sure where to put the keywords so I'll reply to the query with the keywords. Our keywords are:kurtosis, iron, grey matter, aging Conclusion Our findings indicate that kurtosis is associated with iron-sensitive metrics in iron-rich grey matter structures, suggesting that iron deposits may be contributing to kurtosis.

Associations between iron and mean kurtosis in iron-rich grey matter nuclei in aging

期刊论文
发表日期：

2026年4月21日

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Jason Langley,
Kitzia Solis,
Vala Masjedizadeh,
Murphy Shao,
Ilana J. Bennett,
Xiaoping P. Hu

摘要

Objective

Elevated kurtosis values have been observed in subcortical grey matter structures of patients with neurodegenerative diseases. Here, we examined relationships between iron measures and kurtosis in iron-rich subcortical grey matter structures.Please check and confirm the affiliation 4 for the author "Xiaoping P. Hu".Affiliation 4 for Xiaoping P. Hu was incorrect since he is not associated with that department. We have removed this affiliation.Thanks!

Materials and methods

Multi-shell diffusion and multi-echo gradient echo acquisitions were used to derive mean kurtosis and iron measures (R₂* and magnetic susceptibility), respectively, in subcortical grey matter nuclei and white matter tracts in a discovery cohort (110 healthy older and 63 younger adults) and replication cohort (72 healthy older adults).Please confirm if the author names are presented accurately and in the correct sequence (Ilana J. Bennett and Xiaoping P. Hu). Also, kindly confirm the details in the metadata are correct.Thanks for asking. We've checked and the names are presented accurately and in the correct sequence. We have corrected some details in the metadata - adding an affiliation to Murphy Shao (Department of Physics) and removing the Materials Science and Engineering affiliation for Xiaoping P. Hu.Is it possible to add an orcid id for Vala Masjedizadeh? His Orcid ID is 0009-0009-3692-2553Everything else looks okay

Results

Iron-rich grey matter regions exhibited higher mean kurtosis, R₂*, and magnetic susceptibility and white matter regions had lower mean kurtosis in the older adult group from the discovery cohort. In both cohorts, mean kurtosis was significantly correlated with R₂* and magnetic susceptibility in iron-rich grey matter nuclei. No association was seen between signal-to-noise ratio and mean kurtosis in any grey matter region, indicating that the increase in mean kurtosis was not due to reduced signal-to-noise. As keywords are mandatory for this journal, please provide 3-6 keywords.I'm not sure where to put the keywords so I'll reply to the query with the keywords. Our keywords are:kurtosis, iron, grey matter, aging

Conclusion

Our findings indicate that kurtosis is associated with iron-sensitive metrics in iron-rich grey matter structures, suggesting that iron deposits may be contributing to kurtosis.