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Objectives <p>Quantitative muscle MRI (qMRI) is applied to detect muscular alterations, particularly in neuromuscular diseases (NMDs). As studies on rare NMDs benefit from multi-center designs, inter-vendor reproducibility must be assessed to ensure data comparability. However, manufacturer-related variability has been limited investigated. This study evaluates inter-vendor reproducibility of qMRI parameters in healthy subjects.</p> Methods <p>Ten healthy volunteers were investigated within 1 week on two 3T MRI systems (Siemens, Philips). Twelve leg muscles were analyzed using Dixon (fat fraction, FF), T2 mapping (water T2, wT2), and diffusion-weighted-sequence (diffusion parameters: fractional anisotropy (FA), mean, radial, axial diffusivity [MD, RD, <i>λ</i><sub>1</sub>]). Reproducibility was assessed using intraclass correlation coefficient (ICC), within-subject coefficients of variation, <i>t</i> tests, and Bland–Altman analysis.</p> Results <p>ICCs demonstrated moderate to excellent reproducibility for most parameters (ICC<sub>FF</sub> = 0.923, ICC<sub>wT2</sub> = 0.792, ICC<sub>FA</sub> = 0.777, ICC<sub>MD</sub> = 0.708, ICC<sub>RD</sub> = 0.850), except for <i>λ</i><sub>1</sub> (ICC = 0.361). Significant inter-vendor differences were observed for all parameters (<i>p</i> &lt; 0.05), with systematic biases ranging from 44.2% for FF to 3.6% for FA.</p> Discussion <p>qMRI parameters were generally reproducible in healthy volunteers. However, absolute values differed between manufacturers and require correction. These differences should be considered to minimize manufacturer-related discrepancies and to facilitate data pooling in multi-center and longitudinal studies.</p>

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Standardizing quantitative muscle MRI: an inter-vendor evaluation in healthy adults

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月12日

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  • Johanna Thomä,
  • Lionel Butry,
  • Martijn Froeling,
  • Marco Meixner,
  • Johannes Forsting,
  • Lara Schlaffke

摘要

Objectives

Quantitative muscle MRI (qMRI) is applied to detect muscular alterations, particularly in neuromuscular diseases (NMDs). As studies on rare NMDs benefit from multi-center designs, inter-vendor reproducibility must be assessed to ensure data comparability. However, manufacturer-related variability has been limited investigated. This study evaluates inter-vendor reproducibility of qMRI parameters in healthy subjects.

Methods

Ten healthy volunteers were investigated within 1 week on two 3T MRI systems (Siemens, Philips). Twelve leg muscles were analyzed using Dixon (fat fraction, FF), T2 mapping (water T2, wT2), and diffusion-weighted-sequence (diffusion parameters: fractional anisotropy (FA), mean, radial, axial diffusivity [MD, RD, λ1]). Reproducibility was assessed using intraclass correlation coefficient (ICC), within-subject coefficients of variation, t tests, and Bland–Altman analysis.

Results

ICCs demonstrated moderate to excellent reproducibility for most parameters (ICCFF = 0.923, ICCwT2 = 0.792, ICCFA = 0.777, ICCMD = 0.708, ICCRD = 0.850), except for λ1 (ICC = 0.361). Significant inter-vendor differences were observed for all parameters (p < 0.05), with systematic biases ranging from 44.2% for FF to 3.6% for FA.

Discussion

qMRI parameters were generally reproducible in healthy volunteers. However, absolute values differed between manufacturers and require correction. These differences should be considered to minimize manufacturer-related discrepancies and to facilitate data pooling in multi-center and longitudinal studies.