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Objective <p>This work aimed to demonstrate the feasibility of quantifying heart function during bicycling exercise with dynamic real-time cine MRI at 3 Tesla, and to assess its measurement precision.</p> Materials and methods <p>Twelve volunteers performed steady-state bicycling exercise, while real-time cine MR images were collected using a 72-channel receiver coil array and a parallel imaging acceleration factor of 5. Biventricular end-diastolic and end-systolic (ESV) volumes and function during exercise were compared with resting-state real-time cine MRI and conventional cardiac-gated cine MRI under breath holding, and validated against 2D phase-contrast MRI-based estimates of aortic blood flow. Precision was evaluated as the inter-session measurement repeatability.</p> Results <p>Left (LV) and right ventricular (RV) stroke volumes (SV) increased progressively with exercise intensity, which was mediated by a decrease in ESV. Likewise, LV SV estimated with 2D phase-contrast MRI increased from 90 ± 17&#xa0;mL at rest to 114 ± 29&#xa0;mL during vigorous-intensity exercise. Repeatability coefficients were 52% and 41% for LV SV at moderate- and vigorous-intensity exercise, while RV SV repeatability coefficients were 58% and 42%, respectively.</p> Discussion <p>We established an exercise MRI stress testing protocol for quantifying biventricular volumes and function during moderate- and vigorous-intensity steady-state bicycling exercise.</p>

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Exercise MRI stress testing of the human heart at 3 Tesla: measurement precision of biventricular function and aortic blood flow during steady-state bicycling exercise

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月4日

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  • Hugo Klarenberg,
  • Martijn Froeling,
  • Tim Leiner,
  • Hildo J. Lamb,
  • S. Matthijs Boekholdt,
  • Harald T. Jørstad,
  • Gustav J. Strijkers,
  • Adrianus J. Bakermans

摘要

Objective

This work aimed to demonstrate the feasibility of quantifying heart function during bicycling exercise with dynamic real-time cine MRI at 3 Tesla, and to assess its measurement precision.

Materials and methods

Twelve volunteers performed steady-state bicycling exercise, while real-time cine MR images were collected using a 72-channel receiver coil array and a parallel imaging acceleration factor of 5. Biventricular end-diastolic and end-systolic (ESV) volumes and function during exercise were compared with resting-state real-time cine MRI and conventional cardiac-gated cine MRI under breath holding, and validated against 2D phase-contrast MRI-based estimates of aortic blood flow. Precision was evaluated as the inter-session measurement repeatability.

Results

Left (LV) and right ventricular (RV) stroke volumes (SV) increased progressively with exercise intensity, which was mediated by a decrease in ESV. Likewise, LV SV estimated with 2D phase-contrast MRI increased from 90 ± 17 mL at rest to 114 ± 29 mL during vigorous-intensity exercise. Repeatability coefficients were 52% and 41% for LV SV at moderate- and vigorous-intensity exercise, while RV SV repeatability coefficients were 58% and 42%, respectively.

Discussion

We established an exercise MRI stress testing protocol for quantifying biventricular volumes and function during moderate- and vigorous-intensity steady-state bicycling exercise.