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Objective <p>To report <i>T</i><sub>1</sub>/<i>T</i><sub>2</sub>-values of normal and normal appearing brain tissues (NBTs, healthy volunteers; NABTs, patients) acquired with a whole-brain 5-minute Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocol, and to explore relaxometry behavior in a brain tumor and in a multiple sclerosis patient.</p> Methods <p>MR-STAT was acquired in 49 participants (39 patients with neurological pathologies, age range: 21–79&#xa0;years) at 3&#xa0;T. Mean <i>T</i><sub>1</sub>/<i>T</i><sub>2</sub>-values were computed for: normal and normal appearing grey matter (NGM/NAGM)/white matter (NWM/NAWM)/thalamus/putamen/caudate nucleus (CN)/globus pallidus (GP). Differences between sex, brain lobes, and left/right were assessed. The age-dependency of <i>T</i><sub>1</sub>/<i>T</i><sub>2</sub>-values in N(A)BTs was investigated. Relaxometry analysis was performed in two clinical case examples.</p> Results <p>Mean (standard deviation) <i>T</i><sub>1</sub>/<i>T</i><sub>2</sub>-values were measured in N(A)GM = 1086(73)/74(9) ms; N(A)WM = 658(24)/48(3) ms; thalamus = 783(51)/42(4) ms; putamen = 863(40)/46(3) ms; CN = 1042(97)/63(9) ms; GP = 652(36)/36(3) ms. Differences between sex were not significant. <i>T</i><sub>1</sub>/<i>T</i><sub>2</sub>-values between the left/right parietal lobe and the left/right temporal lobe were significantly different. The quadratic age-dependency of <i>T</i><sub>1</sub>-values in the CN (<i>p</i> = 0.00039) and GP (<i>p</i> = 0.00037), and of <i>T</i><sub>2</sub>-values in the thalamus (<i>p</i> = 0.00044) and GP (<i>p</i> = 0.003) were significant. Pathological tissues could be discerned from NABTs using <i>T</i><sub>1</sub>/<i>T</i><sub>2</sub>-values.</p> Discussion <p><i>T</i><sub>1</sub>/<i>T</i><sub>2</sub>-values and data trends agree with literature, supporting the validity of MR-STAT as a clinical option for fast relaxometry despite the relatively low number of subjects in the study. Future work should aim to include healthy participants of a wider age-range and to include B<sub>1</sub>-field corrections.</p>

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Fast whole brain relaxometry with Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) at 3 T: a retrospective cohort study

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  • 发表日期：

    2025年3月4日

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  • Martin B. Schilder,
  • Stefano Mandija,
  • Sarah M. Jacobs,
  • Jordi P. D. Kleinloog,
  • Hanna Liu,
  • Oscar van der Heide,
  • Beyza Köktaş,
  • Federico D’Agata,
  • Vera C. W. Keil,
  • Evert-Jan P. A. Vonken,
  • Jan Willem Dankbaar,
  • Jeroen Hendrikse,
  • Tom J. Snijders,
  • Cornelis A. T. van den Berg,
  • Anja G. van der Kolk,
  • Alessandro Sbrizzi

摘要

Objective

To report T1/T2-values of normal and normal appearing brain tissues (NBTs, healthy volunteers; NABTs, patients) acquired with a whole-brain 5-minute Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocol, and to explore relaxometry behavior in a brain tumor and in a multiple sclerosis patient.

Methods

MR-STAT was acquired in 49 participants (39 patients with neurological pathologies, age range: 21–79 years) at 3 T. Mean T1/T2-values were computed for: normal and normal appearing grey matter (NGM/NAGM)/white matter (NWM/NAWM)/thalamus/putamen/caudate nucleus (CN)/globus pallidus (GP). Differences between sex, brain lobes, and left/right were assessed. The age-dependency of T1/T2-values in N(A)BTs was investigated. Relaxometry analysis was performed in two clinical case examples.

Results

Mean (standard deviation) T1/T2-values were measured in N(A)GM = 1086(73)/74(9) ms; N(A)WM = 658(24)/48(3) ms; thalamus = 783(51)/42(4) ms; putamen = 863(40)/46(3) ms; CN = 1042(97)/63(9) ms; GP = 652(36)/36(3) ms. Differences between sex were not significant. T1/T2-values between the left/right parietal lobe and the left/right temporal lobe were significantly different. The quadratic age-dependency of T1-values in the CN (p = 0.00039) and GP (p = 0.00037), and of T2-values in the thalamus (p = 0.00044) and GP (p = 0.003) were significant. Pathological tissues could be discerned from NABTs using T1/T2-values.

Discussion

T1/T2-values and data trends agree with literature, supporting the validity of MR-STAT as a clinical option for fast relaxometry despite the relatively low number of subjects in the study. Future work should aim to include healthy participants of a wider age-range and to include B1-field corrections.