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<p>The type III secretion system (T3SS) is essential for <i>Ralstonia pseudosolanacearum</i> to infect host plants. Transcription of the T3SS genes was not activated in nutrient-rich casamino acid-peptone-glucose (CPG) broth, but activated in a minimal medium that might mimic metabolic signals of the host plant. CPG broth at 5% substantially impaired expression of T3SS genes. In tests of T3SS gene expression, <span>l</span>-lysine was found to be a novel inhibitor of expression of T3SS genes in non-acidic conditions and significantly impaired their expression via a PrhG-HrpB pathway and their motility and biofilm formation, which are also important for pathogenicity, and led to significant inhibition of symptom development in tomato plants.</p>

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Lysine inhibition of expression of genes encoding type III secretion system in Ralstonia pseudosolanacearum and its virulence in host plants

  • 期刊论文

  • 发表日期：

    2025年8月6日

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  • Liangliang Han,
  • Runxiao Li,
  • Jiajun Huang,
  • Xia Xiao,
  • Ping Ouyang,
  • Tao Liang,
  • Tao Guo,
  • Yasufumi Hikichi,
  • Kouhei Ohnishi,
  • Yong Zhang

摘要

The type III secretion system (T3SS) is essential for Ralstonia pseudosolanacearum to infect host plants. Transcription of the T3SS genes was not activated in nutrient-rich casamino acid-peptone-glucose (CPG) broth, but activated in a minimal medium that might mimic metabolic signals of the host plant. CPG broth at 5% substantially impaired expression of T3SS genes. In tests of T3SS gene expression, l-lysine was found to be a novel inhibitor of expression of T3SS genes in non-acidic conditions and significantly impaired their expression via a PrhG-HrpB pathway and their motility and biofilm formation, which are also important for pathogenicity, and led to significant inhibition of symptom development in tomato plants.