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Background <p>Vascular epilepsies can manifest at various stages of adulthood and are often accompanied by age-related comorbidities. Aging processes, particularly vascular and neurodegenerative changes, contribute significantly to the risk of late-onset epilepsy (LOE).</p> Methods <p>This narrative review explores the emerging role of the glymphatic system in the pathogenesis of vascular-related adult-onset epilepsy in the context of aging. Both established antiseizure medications (ASMs) and novel preventive strategies currently under investigation are evaluated.</p> Results and conclusion <p>The review emphasizes the importance of an interdisciplinary management approach and discusses practical considerations for optimizing care in this patient population.</p>

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Vascular epilepsy in adulthood: current status and outlook for research and management

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月18日

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  • Hermann Stefan,
  • Ernst Thilo Hammen,
  • Vineet Punia

摘要

Background

Vascular epilepsies can manifest at various stages of adulthood and are often accompanied by age-related comorbidities. Aging processes, particularly vascular and neurodegenerative changes, contribute significantly to the risk of late-onset epilepsy (LOE).

Methods

This narrative review explores the emerging role of the glymphatic system in the pathogenesis of vascular-related adult-onset epilepsy in the context of aging. Both established antiseizure medications (ASMs) and novel preventive strategies currently under investigation are evaluated.

Results and conclusion

The review emphasizes the importance of an interdisciplinary management approach and discusses practical considerations for optimizing care in this patient population.