Tonisch-klonischer Anfall unter Lamotrigin und Metamizol
摘要
We report the case of a tonic-clonic seizure on a stable dose of lamotrigine after long-standing treatment of idiopathic generalized epilepsy. Prior to the recurrence the patient underwent postoperative pain treatment with dipyrone for 1 week, a moderate to strong enzyme inducer. The time course of the lamotrigine levels and the pharmacokinetics of induced glucuronidation are discussed.