<p>We report the case of a&#xa0;tonic-clonic seizure on a&#xa0;stable dose of lamotrigine after long-standing treatment of idiopathic generalized epilepsy. Prior to the recurrence the patient underwent postoperative pain treatment with dipyrone for 1 week, a&#xa0;moderate to strong enzyme inducer. The time course of the lamotrigine levels and the pharmacokinetics of induced glucuronidation are discussed.</p>

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Tonisch-klonischer Anfall unter Lamotrigin und Metamizol

  • Bert-Ulrich Kleine,
  • Annemarie Fugmann,
  • Ragna-Jill Miosge,
  • Jörg Berrouschot

摘要

We report the case of a tonic-clonic seizure on a stable dose of lamotrigine after long-standing treatment of idiopathic generalized epilepsy. Prior to the recurrence the patient underwent postoperative pain treatment with dipyrone for 1 week, a moderate to strong enzyme inducer. The time course of the lamotrigine levels and the pharmacokinetics of induced glucuronidation are discussed.