Kontrazeption bei Mamma- und Ovarialkarzinom – sind Hormone eine Option?
摘要
Contraception in women with breast and ovarian cancer is complex as effective pregnancy prevention must be balanced against potential hormonal interactions with the oncological disease.
ObjectiveSummary of the current evidence on the safety and suitability of hormonal and nonhormonal contraceptive methods in these patients.
MethodsNarrative review of current studies and clinical guidelines addressing contraception in breast and ovarian cancer.
ResultsNonhormonal methods are universally applicable and oncologically safe, with copper intrauterine devices (IUD) and permanent procedures providing the highest contraceptive safety. Hormonal contraception is associated with a slight increase in the risk for breast cancer and a potential increased risk of recurrence cannot be excluded. Therefore, guidelines advise against the use of hormonal methods. In ovarian cancer hormonal contraceptives are associated with a protective effect with respect to the primary incidence of disease, while data regarding recurrence risk are limited and inconsistent.
ConclusionThe choice of contraceptive requires an individualized risk-benefit assessment considering the tumor characteristics, comorbidities and patient preferences.