Risiko endokriner Interventionen bei Trägerinnen einer genetischen Disposition für Brustkrebs und gynäkologische Krebserkrankungen
摘要
Women with a genetic predisposition for breast and gynecologic cancer have concerns that hormonal interventions could increase their genetic cancer risk. As a result, they are often excluded from endocrine interventions for fertility treatment, contraception, hormone replacement after risk-reducing salpingo-oophorectomy (RRSO), or from treatment of peri- and postmenopausal symptoms. The following statements and recommendations were formulated by the Hormone Working Group of the German Consortium for Hereditary Breast and Ovarian Cancer and are meant to support physicians in counseling affected women.