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Purpose <p>To evaluate the association between early childhood respiratory problems and Molar-Incisor Hypomineralization (MIH).</p> Methods <p>Observational studies assessing the relationship between early respiratory diseases and MIH were included. Two independent reviewers conducted comprehensive searches in MEDLINE-PubMed, Scopus, EMBASE, Web of Science, Google Scholar<sup>®</sup>, and OpenGrey<sup>®</sup>. This systematic review followed PRISMA guidelines and was registered in the PROSPERO database (CRD42022320707). Risk of bias was assessed using the Joanna Briggs Institute (JBI) checklist for cross-sectional studies and the Newcastle–Ottawa Scale for case–control and cohort studies. The certainty of the evidence was rated using the GRADE framework. Meta-analyses were performed to explore associations between respiratory conditions and MIH (significance level p &lt; 0.05).</p> Results <p>From 1228 identified articles, 27 met the inclusion criteria, and 12 were included in four meta-analyses. Most cross-sectional and cohort studies showed low risk of bias, while case–control studies showed moderate risk. Quantitative synthesis was feasible only for asthma and pneumonia. In adjusted analyses, asthma was not significantly associated with MIH (OR 1.93; 95% CI 0.60–6.20), with substantial heterogeneity across studies. Pneumonia showed a positive overall association with MIH (OR 3.33; 95% CI 1.05–10.51). However, the certainty of evidence for all associations was considered very low.</p> Conclusion <p>Early childhood respiratory conditions may be associated with molar–incisor hypomineralization, but the available evidence is inconsistent and of very low certainty, precluding causal inference.</p>

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Respiratory problems in early childhood and molar-incisor hypomineralization: systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月10日

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  • Ronney Brandão Osterno,
  • Lara Carvalho Costa,
  • Francisco Wilker Mustafa Gomes Muniz,
  • Marta Maria Alves Pereira,
  • Marcoeli Silva de Moura,
  • Cacilda Castelo Branco Lima,
  • Lúcia de Fátima Almeida de Deus Moura,
  • Marina de Deus Moura Lima

摘要

Purpose

To evaluate the association between early childhood respiratory problems and Molar-Incisor Hypomineralization (MIH).

Methods

Observational studies assessing the relationship between early respiratory diseases and MIH were included. Two independent reviewers conducted comprehensive searches in MEDLINE-PubMed, Scopus, EMBASE, Web of Science, Google Scholar®, and OpenGrey®. This systematic review followed PRISMA guidelines and was registered in the PROSPERO database (CRD42022320707). Risk of bias was assessed using the Joanna Briggs Institute (JBI) checklist for cross-sectional studies and the Newcastle–Ottawa Scale for case–control and cohort studies. The certainty of the evidence was rated using the GRADE framework. Meta-analyses were performed to explore associations between respiratory conditions and MIH (significance level p < 0.05).

Results

From 1228 identified articles, 27 met the inclusion criteria, and 12 were included in four meta-analyses. Most cross-sectional and cohort studies showed low risk of bias, while case–control studies showed moderate risk. Quantitative synthesis was feasible only for asthma and pneumonia. In adjusted analyses, asthma was not significantly associated with MIH (OR 1.93; 95% CI 0.60–6.20), with substantial heterogeneity across studies. Pneumonia showed a positive overall association with MIH (OR 3.33; 95% CI 1.05–10.51). However, the certainty of evidence for all associations was considered very low.

Conclusion

Early childhood respiratory conditions may be associated with molar–incisor hypomineralization, but the available evidence is inconsistent and of very low certainty, precluding causal inference.