Scholarlink

Objective <p>Transplantation-associated thrombotic microangiopathy (TA-TMA) is a severe thrombotic complication that occurs after hematopoietic stem cell transplantation. Currently, there are no clear conclusions on the factors influencing the prognosis of TA-TMA patients and the best treatment plan for TA-TMA.</p> Methods <p>We retrospectively collected information on 26 patients with TA-TMA from a single center. The independent factors affecting prognosis were analyzed through univariate and multivariate Cox regression. Subgroup analysis was also conducted to investigate the impact of different treatment methods on overall survival of patients.</p> Results <p>We found that high creatinine levels during the diagnosis of TA-TMA and previous CAR-T cell therapy were independent risk factors affecting the prognosis of TA-TMA patients. Additionally, discontinuing calcineurin inhibitors (CNI) is helpful in prolonging the survival period of TA-TMA patients.</p> Conclusions <p>Our research has revealed the high-risk factors affecting the survival of TA-TMA patients and the efficacy of different treatment methods, providing guidance for subsequent clinical practice.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Analysis of prognostic factors affecting TA-TMA patients: a single-center retrospective study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月4日

查看全文
  • Jile Liu,
  • Haotian Meng,
  • Tao Zhang,
  • Xiu Liu,
  • Mingfeng Zhao

摘要

Objective

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a severe thrombotic complication that occurs after hematopoietic stem cell transplantation. Currently, there are no clear conclusions on the factors influencing the prognosis of TA-TMA patients and the best treatment plan for TA-TMA.

Methods

We retrospectively collected information on 26 patients with TA-TMA from a single center. The independent factors affecting prognosis were analyzed through univariate and multivariate Cox regression. Subgroup analysis was also conducted to investigate the impact of different treatment methods on overall survival of patients.

Results

We found that high creatinine levels during the diagnosis of TA-TMA and previous CAR-T cell therapy were independent risk factors affecting the prognosis of TA-TMA patients. Additionally, discontinuing calcineurin inhibitors (CNI) is helpful in prolonging the survival period of TA-TMA patients.

Conclusions

Our research has revealed the high-risk factors affecting the survival of TA-TMA patients and the efficacy of different treatment methods, providing guidance for subsequent clinical practice.