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<p>Ca<sup>2+</sup>, as critical second messengers in biological processes, plays a pivotal role in the regulation of diverse cellular signaling pathways. The dysregulation of calcium signaling is intricately linked to the progression of various cancers. The capacity of Ca<sup>2+</sup> to modulate cell death and proliferation, along with its potential for pharmacological manipulation, presents a promising avenue for the development of novel cancer therapeutics. This review provides a comprehensive overview of the classification of Ca<sup>2+</sup> channels and their mechanisms of action in oncogenesis, explores the application of Ca<sup>2+</sup> blockers in cancer treatment, and underscores the importance of conducting further clinical trials.</p>

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Calcium channels as pharmacological targets for cancer therapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月25日

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  • Xiaozhen Liu,
  • Changyun Feng,
  • Li Yan,
  • Jili Cao,
  • Xinping Zhu,
  • Mingqian Li,
  • Guizhi Zhao

摘要

Ca2+, as critical second messengers in biological processes, plays a pivotal role in the regulation of diverse cellular signaling pathways. The dysregulation of calcium signaling is intricately linked to the progression of various cancers. The capacity of Ca2+ to modulate cell death and proliferation, along with its potential for pharmacological manipulation, presents a promising avenue for the development of novel cancer therapeutics. This review provides a comprehensive overview of the classification of Ca2+ channels and their mechanisms of action in oncogenesis, explores the application of Ca2+ blockers in cancer treatment, and underscores the importance of conducting further clinical trials.