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<p>When a Transcatheter heart valve (THV) is implanted in a bicuspid aortic valve (BAV), the interventional valve may experience elliptical deformation, thereby reducing its durability. In this study, a novel Asymmetric Artificial Interventional Valve (AAIV) was designed. The deployment of the AAIV in the BAV was simulated and compared to that of a THV. The synergistic effects of the AAIV (0.1, 0.2, and 0.3) eccentricity and annulus eccentricity (0.1, 0.2, and 0.3) on the deployment of the interventional valve were studied. Besides, the influence of native leaflet calcification on the deployment of the AAIV was also studied. The results demonstrated the maximum stress of the AAIV (0.590&#xa0;MPa) is 8.2% lower than that of the THV (0.643&#xa0;MPa). When the AAIV eccentricity is equal to the annulus eccentricity, the stress of the prosthetic valve is the highest, representing the most unfavorable condition for the long-term durability of the prosthetic valve. Calcification of the native leaflet can increase the stress of the prosthetic valve. In addition, with the increase of annulus eccentricity, the stress of the prosthetic valve tends to increase. This study might provide insights for the design of personalized high-performance interventional valves and their rational selection in clinical practice.</p>

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Mechanical behaviors of an asymmetric transcatheter prosthetic valve in bicuspid aortic valve

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Xiang Shen,
  • Huilin Yao,
  • Zewen He,
  • Yue Xu,
  • Jiahao Chen,
  • Jianwei Gao,
  • Yizhe Wang,
  • Qiang Liu,
  • Yuan Wang,
  • Hongyu Liang

摘要

When a Transcatheter heart valve (THV) is implanted in a bicuspid aortic valve (BAV), the interventional valve may experience elliptical deformation, thereby reducing its durability. In this study, a novel Asymmetric Artificial Interventional Valve (AAIV) was designed. The deployment of the AAIV in the BAV was simulated and compared to that of a THV. The synergistic effects of the AAIV (0.1, 0.2, and 0.3) eccentricity and annulus eccentricity (0.1, 0.2, and 0.3) on the deployment of the interventional valve were studied. Besides, the influence of native leaflet calcification on the deployment of the AAIV was also studied. The results demonstrated the maximum stress of the AAIV (0.590 MPa) is 8.2% lower than that of the THV (0.643 MPa). When the AAIV eccentricity is equal to the annulus eccentricity, the stress of the prosthetic valve is the highest, representing the most unfavorable condition for the long-term durability of the prosthetic valve. Calcification of the native leaflet can increase the stress of the prosthetic valve. In addition, with the increase of annulus eccentricity, the stress of the prosthetic valve tends to increase. This study might provide insights for the design of personalized high-performance interventional valves and their rational selection in clinical practice.