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<p>Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) is a type of mechanical circulatory support used, among others, in case of cardiogenic shock, consisting in percutaneous cannulation of the femoral artery. Despite the widespread use of this procedure in clinical practice, a deeper understanding of the complex interaction between native and ECMO output, as well as the fluid dynamics and perfusion of aorta and its branches is still required. Herein, a numerical and experimental approach is presented to model a VA-ECMO procedure on a patient-specific aortic geometry. For both approaches, cardiogenic shock was modeled by considering three different severities of left ventricular failure (mild, moderate, and severe), corresponding to a reduction in cardiac output of 30%, 50%, and 70% relative to the healthy condition, respectively. For each case, different levels of the ECMO support were simulated, ranging from 0 to 6&#xa0;l/min. The performance of the VA-ECMO configuration was evaluated in terms of both afterload increase and flow at all aortic branches. Both methods highlighted the afterload increase in high levels of ECMO support. Furthermore, numerical and experimental data revealed the existence of a trade-off level of ECMO support that guarantees healthy perfusion of all vessels with the lowest afterload. This correlation opened a pathway for the definition of a tool for determining a suitable level of ECMO support on the basis of the knowledge of patient-specific data.</p>

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A computational and experimental study of veno-arterial extracorporeal membrane oxygenation in cardiogenic shock: defining the trade-off between perfusion and afterload

  • 期刊论文

  • 发表日期：

    2025年4月16日

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  • Emanuele Gasparotti,
  • Emanuele Vignali,
  • Massimo Scolaro,
  • Dorela Haxhiademi,
  • Simona Celi

摘要

Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) is a type of mechanical circulatory support used, among others, in case of cardiogenic shock, consisting in percutaneous cannulation of the femoral artery. Despite the widespread use of this procedure in clinical practice, a deeper understanding of the complex interaction between native and ECMO output, as well as the fluid dynamics and perfusion of aorta and its branches is still required. Herein, a numerical and experimental approach is presented to model a VA-ECMO procedure on a patient-specific aortic geometry. For both approaches, cardiogenic shock was modeled by considering three different severities of left ventricular failure (mild, moderate, and severe), corresponding to a reduction in cardiac output of 30%, 50%, and 70% relative to the healthy condition, respectively. For each case, different levels of the ECMO support were simulated, ranging from 0 to 6 l/min. The performance of the VA-ECMO configuration was evaluated in terms of both afterload increase and flow at all aortic branches. Both methods highlighted the afterload increase in high levels of ECMO support. Furthermore, numerical and experimental data revealed the existence of a trade-off level of ECMO support that guarantees healthy perfusion of all vessels with the lowest afterload. This correlation opened a pathway for the definition of a tool for determining a suitable level of ECMO support on the basis of the knowledge of patient-specific data.