Scholarlink

<p>Mild traumatic brain injury (mTBI) represents a significant public health challenge in modern society. An in-depth analysis of the injury mechanisms, pathological forms, and assessment criteria of mTBI has underscored the pivotal role of craniocerebral models in comprehending and addressing mTBI. Research indicates that although existing finite element craniocerebral models have made strides in simulating the macroscopic biomechanical responses of the brain, they still fall short in accurately depicting the complexity of mTBI. Consequently, this paper emphasizes the necessity of integrating biomechanics, neuropathology, and neuroimaging to develop multiscale and multiphysics craniocerebral models, which are crucial for precisely capturing microscopic injuries, establishing pathological mechanical indicators, and simulating secondary and long-term brain functional impairments. The comprehensive analysis and in-depth discussion presented in this paper offer new perspectives and approaches for understanding, diagnosing, and preventing mTBI, potentially contributing to alleviating the global burden of mTBI.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bridging biomechanics with neuropathological and neuroimaging insights for mTBI understanding through multiscale and multiphysics computational modeling

  • 期刊论文

  • 发表日期：

    2025年2月11日

查看全文
  • Zhibo Du,
  • Jiarui Zhang,
  • Xinghao Wang,
  • Zhuo Zhuang,
  • Zhanli Liu

摘要

Mild traumatic brain injury (mTBI) represents a significant public health challenge in modern society. An in-depth analysis of the injury mechanisms, pathological forms, and assessment criteria of mTBI has underscored the pivotal role of craniocerebral models in comprehending and addressing mTBI. Research indicates that although existing finite element craniocerebral models have made strides in simulating the macroscopic biomechanical responses of the brain, they still fall short in accurately depicting the complexity of mTBI. Consequently, this paper emphasizes the necessity of integrating biomechanics, neuropathology, and neuroimaging to develop multiscale and multiphysics craniocerebral models, which are crucial for precisely capturing microscopic injuries, establishing pathological mechanical indicators, and simulating secondary and long-term brain functional impairments. The comprehensive analysis and in-depth discussion presented in this paper offer new perspectives and approaches for understanding, diagnosing, and preventing mTBI, potentially contributing to alleviating the global burden of mTBI.