<p>This systematic literature review examines the role of cultural dimensions in user interface (UI) design and user experience (UX), with a focus on the comparative effectiveness of culturally adaptive versus culturally neutral interfaces. The review synthesises 19 peer-reviewed empirical articles published between 2020 and 2024, identified through a systematic multi-stage screening process across five leading academic databases, following PRISMA guidelines to ensure transparency and reproducibility. The findings indicate that cultural dimensions, particularly individualism/collectivism, uncertainty avoidance, and power distance, as conceptualised in Hofstede’s framework, significantly influence user interaction behaviours and technology usability. Across the reviewed studies, culturally adaptive interfaces tend to yield higher levels of user satisfaction and engagement compared to culturally neutral designs, although this pattern is most evident within specific regional contexts. The review acknowledges a pronounced geographic concentration, with the majority of included studies drawing on participants from Asia and the Middle East. The findings should therefore be interpreted as regionally situated rather than universally generalisable. This review provides an integrated synthesis across multiple application domains, including mHealth, e-learning, e-commerce, and immersive technologies. It also identifies persistent gaps in cross-cultural UI/UX research, including limited geographic representation, continued reliance on Hofstede’s framework, and the early-stage development of culturally responsive design in augmented reality (AR) and virtual reality (VR) environments.</p>