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Background <p>Cognitive impairment is highly prevalent among older adults receiving maintenance hemodialysis; however, its pathophysiology is multifactorial and poorly understood. Evidence linking the lipid-profile components to cognitive function in patients undergoing hemodialysis remains limited. To address this evidence gap, we evaluated the associations between serum lipid-profile components and global cognitive function.</p> Methods <p>We conducted an exploratory cross-sectional study of patients aged ≥ 65&#xa0;years receiving maintenance hemodialysis at seven dialysis centers in Japan. Serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels were measured immediately before the first hemodialysis session of the week. Global cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Multivariate linear regression analyses were performed, adjusting for clinical comorbidities and markers of nutritional status, inflammation, and dialysis adequacy.</p> Results <p>Among 265 participants (median age, 74&#xa0;years; 67.6% male), higher serum HDL-C levels were independently associated with higher MoCA scores (fully adjusted model: β = 0.06; 95% confidence interval, 0.03–0.10; <i>P</i> &lt; 0.001) and MMSE scores (β = 0.03; 95% confidence interval, 0.01–0.06; <i>P</i> = 0.031). In contrast, the serum LDL-C and TG levels showed no significant associations with either cognitive assessment.</p> Conclusion <p>Higher serum HDL-C levels were associated with better global cognitive function in older patients undergoing hemodialysis, whereas the LDL-C and TG levels were not significantly related to cognitive scores.</p>

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High-density lipoprotein cholesterol and cognitive function in patients undergoing hemodialysis

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Kazuhiko Kato,
  • Akio Nakashima,
  • Chiharu Aizawa,
  • Arisa Kobayashi,
  • Shunichiro Shinagawa,
  • Ichiro Ohkido,
  • Mitsuyoshi Urashima,
  • Takashi Yokoo

摘要

Background

Cognitive impairment is highly prevalent among older adults receiving maintenance hemodialysis; however, its pathophysiology is multifactorial and poorly understood. Evidence linking the lipid-profile components to cognitive function in patients undergoing hemodialysis remains limited. To address this evidence gap, we evaluated the associations between serum lipid-profile components and global cognitive function.

Methods

We conducted an exploratory cross-sectional study of patients aged ≥ 65 years receiving maintenance hemodialysis at seven dialysis centers in Japan. Serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels were measured immediately before the first hemodialysis session of the week. Global cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Multivariate linear regression analyses were performed, adjusting for clinical comorbidities and markers of nutritional status, inflammation, and dialysis adequacy.

Results

Among 265 participants (median age, 74 years; 67.6% male), higher serum HDL-C levels were independently associated with higher MoCA scores (fully adjusted model: β = 0.06; 95% confidence interval, 0.03–0.10; P < 0.001) and MMSE scores (β = 0.03; 95% confidence interval, 0.01–0.06; P = 0.031). In contrast, the serum LDL-C and TG levels showed no significant associations with either cognitive assessment.

Conclusion

Higher serum HDL-C levels were associated with better global cognitive function in older patients undergoing hemodialysis, whereas the LDL-C and TG levels were not significantly related to cognitive scores.