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Background <p>This study investigated whether low-phosphate boiled-meat meals (LP meals), provided together with a fixed minimal dose of calcium carbonate (CaCO<sub>3</sub>), could help maintain stable CKD-MBD and inflammatory indicators in maintenance hemodialysis (MHD) patients, compared with standard meals receiving the <i>same</i> CaCO<sub>3</sub> dose.</p> Methods <p>Participants completed an adaptation diet followed by 7&#xa0;days of LP meals or standard control meals. Both groups received an identical minimal dose of CaCO<sub>3</sub> (1 tablet/meal) to ensure equivalent binder exposure. Blood CKD-MBD parameters, inflammatory markers, and dietary intake were assessed at baseline and after the intervention.</p> Results <p>Forty patients completed the study (LP group, n = 20; control group, n = 20). Serum phosphate levels increased significantly in the control group after the intervention but remained stable in the LP group (2nd 6.61 ± 2.04&#xa0;mg/dL vs. 1st 5.61 ± 1.14&#xa0;mg/dL; <i>P</i> &lt; 0.05). Reductions in tumor necrosis factor-α and serum calcium from baseline were significantly greater in the LP group than in the control group (both P &lt; 0.05).</p> Conclusion <p>The LP meals, when consumed with a controlled, minimal CaCO3 dose, helped prevent increases in blood phosphate, hypercalcemia, and inflammation compared with standard meals that received the same binder dose.</p>

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Effects of low-phosphate boiled-meat meal on CKD-MBD and inflammatory indicators in maintenance hemodialysis patients with controlled calcium carbonate dosing

  • 期刊论文

  • 发表日期：

    2026年3月12日

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  • Barbara Ying-Jung Chen,
  • Mei-Yi Wu,
  • Mei-Yun Chin,
  • Mai-Szu Wu,
  • Jiun-Rong Chen

摘要

Background

This study investigated whether low-phosphate boiled-meat meals (LP meals), provided together with a fixed minimal dose of calcium carbonate (CaCO3), could help maintain stable CKD-MBD and inflammatory indicators in maintenance hemodialysis (MHD) patients, compared with standard meals receiving the same CaCO3 dose.

Methods

Participants completed an adaptation diet followed by 7 days of LP meals or standard control meals. Both groups received an identical minimal dose of CaCO3 (1 tablet/meal) to ensure equivalent binder exposure. Blood CKD-MBD parameters, inflammatory markers, and dietary intake were assessed at baseline and after the intervention.

Results

Forty patients completed the study (LP group, n = 20; control group, n = 20). Serum phosphate levels increased significantly in the control group after the intervention but remained stable in the LP group (2nd 6.61 ± 2.04 mg/dL vs. 1st 5.61 ± 1.14 mg/dL; P < 0.05). Reductions in tumor necrosis factor-α and serum calcium from baseline were significantly greater in the LP group than in the control group (both P < 0.05).

Conclusion

The LP meals, when consumed with a controlled, minimal CaCO3 dose, helped prevent increases in blood phosphate, hypercalcemia, and inflammation compared with standard meals that received the same binder dose.